About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bmp4tm3Blh
targeted mutation 3, Brigid L Hogan
MGI:2181188
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bmp4tm3Blh/Bmp4tm3Blh involves: 129S6/SvEvTac MGI:3811332
hm2
 		Bmp4tm3Blh/Bmp4tm3Blh involves: 129S6/SvEvTac * Black Swiss MGI:2183178
ht3
 		Bmp4tm3Blh/Bmp4+ involves: 129S6/SvEvTac MGI:3811333
cn4
 		Bmp4tm3Blh/Bmp4tm3Blh
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:2661104
cn5
 		Bmp4tm3Blh/Bmp4+
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3811334


Genotype
MGI:3811332
hm1
Allelic
Composition		 Bmp4tm3Blh/Bmp4tm3Blh
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3Blh mutation (0 available); any Bmp4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:83123 )
• significant loss of embryos between E12.5 and E14.5

vision/eye
abnormal eye development ( J:83123 )
• severely deficient




Genotype
MGI:2183178
hm2
Allelic
Composition		 Bmp4tm3Blh/Bmp4tm3Blh
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3Blh mutation (0 available); any Bmp4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:75136 )
• less than half of animals survive until weaning

behavior/neurological
circling ( J:75136 )
• extreme circling behavior

vision/eye




Genotype
MGI:3811333
ht3
Allelic
Composition		 Bmp4tm3Blh/Bmp4+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3Blh mutation (0 available); any Bmp4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:83123 )
• fewer mice survive to birth than expected




Genotype
MGI:2661104
cn4
Allelic
Composition		 Bmp4tm3Blh/Bmp4tm3Blh
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3Blh mutation (0 available); any Bmp4 mutation (21 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:83123 )
• all die between E12.5 and E14.5
• only necrotic embryos are found at E14.5

craniofacial
retrognathia ( J:83123 )
• recessed jaws
abnormal snout morphology ( J:83123 )
• recessed snout

vision/eye
abnormal eye development ( J:83123 )
• severely deficient

nervous system
nervous system phenotype ( J:83123 )
N
• despite Cre-mediated deletion in the telencephalon, no defects in telencephalic patterning or development are detected

skeleton
retrognathia ( J:83123 )
• recessed jaws

growth/size/body
abnormal face development ( J:83123 )
abnormal snout morphology ( J:83123 )
• recessed snout




Genotype
MGI:3811334
cn5
Allelic
Composition		 Bmp4tm3Blh/Bmp4+
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3Blh mutation (0 available); any Bmp4 mutation (21 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:83123 )
• fewer mice survive to birth than expected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory