All Phenotypes Bmp4<tm3Blh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bmp4^tm3Blh
targeted mutation 3, Brigid L Hogan
MGI:2181188

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp4^tm3Blh/Bmp4^tm3Blh	involves: 129S6/SvEvTac	MGI:3811332
hm2	Bmp4^tm3Blh/Bmp4^tm3Blh	involves: 129S6/SvEvTac * Black Swiss	MGI:2183178
ht3	Bmp4^tm3Blh/Bmp4⁺	involves: 129S6/SvEvTac	MGI:3811333
cn4	Bmp4^tm3Blh/Bmp4^tm3Blh Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:2661104
cn5	Bmp4^tm3Blh/Bmp4⁺ Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:3811334

Allelic Composition	Bmp4^tm3Blh/Bmp4^tm3Blh
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm3Blh mutation (0 available); any Bmp4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:83123 )

• significant loss of embryos between E12.5 and E14.5

vision/eye

abnormal eye development ( J:83123 )

• severely deficient

Allelic Composition	Bmp4^tm3Blh/Bmp4^tm3Blh
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm3Blh mutation (0 available); any Bmp4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:75136 )

• less than half of animals survive until weaning

behavior/neurological

circling ( J:75136 )

• extreme circling behavior

vision/eye

abnormal eye morphology ( J:75136 )

eyelids fail to open ( J:75136 )

Allelic Composition	Bmp4^tm3Blh/Bmp4⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm3Blh mutation (0 available); any Bmp4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:83123 )

• fewer mice survive to birth than expected

Allelic Composition	Bmp4^tm3Blh/Bmp4^tm3Blh Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm3Blh mutation (0 available); any Bmp4 mutation (23 available)
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:83123 )

• all die between E12.5 and E14.5

• only necrotic embryos are found at E14.5

craniofacial

retrognathia ( J:83123 )

• recessed jaws

abnormal face development ( J:83123 )

abnormal snout morphology ( J:83123 )

• recessed snout

vision/eye

abnormal eye development ( J:83123 )

• severely deficient

nervous system

nervous system phenotype ( J:83123 )

N	• despite Cre-mediated deletion in the telencephalon, no defects in telencephalic patterning or development are detected

skeleton

retrognathia ( J:83123 )

• recessed jaws

growth/size/body

retrognathia ( J:83123 )

• recessed jaws

abnormal face development ( J:83123 )

abnormal snout morphology ( J:83123 )

• recessed snout

Allelic Composition	Bmp4^tm3Blh/Bmp4⁺ Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:83123 )

• fewer mice survive to birth than expected

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