cardiovascular system
• right atrium enlarged at 6 weeks of age
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• right atrium/body weight ratio increased 51% over controls
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• all chambers of the heart enlarged at 24 weeks of age
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• at 24 weeks of age but normal myocardial histology
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• increased end-systolic dimensions and end-systolic volume
• reduced fractional shortening of myofibers
• diminished velocity of fiber shortening
• decreased ejection fractions at 10 and 24 weeks of age
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• myocardial hypertrophy
• systolic dysfunction
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muscle
• at 24 weeks of age but normal myocardial histology
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• increased end-systolic dimensions and end-systolic volume
• reduced fractional shortening of myofibers
• diminished velocity of fiber shortening
• decreased ejection fractions at 10 and 24 weeks of age
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• myocardial hypertrophy
• systolic dysfunction
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growth/size/body
• all chambers of the heart enlarged at 24 weeks of age
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• at 24 weeks of age but normal myocardial histology
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