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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Irx4tm1Jse
targeted mutation 1, Jonathon G Seidman
MGI:2180895
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Irx4tm1Jse/Irx4tm1Jse involves: 129X1/SvJ * Black Swiss MGI:3584146
ht2
Irx4tm1Jse/Irx4+ involves: 129X1/SvJ * Black Swiss MGI:3584147


Genotype
MGI:3584146
hm1
Allelic
Composition
Irx4tm1Jse/Irx4tm1Jse
Genetic
Background
involves: 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx4tm1Jse mutation (0 available); any Irx4 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• right atrium enlarged at 6 weeks of age
• right atrium/body weight ratio increased 51% over controls
• all chambers of the heart enlarged at 24 weeks of age
• at 24 weeks of age but normal myocardial histology
• increased end-systolic dimensions and end-systolic volume
• reduced fractional shortening of myofibers
• diminished velocity of fiber shortening
• decreased ejection fractions at 10 and 24 weeks of age
• myocardial hypertrophy
• systolic dysfunction

muscle
• at 24 weeks of age but normal myocardial histology
• increased end-systolic dimensions and end-systolic volume
• reduced fractional shortening of myofibers
• diminished velocity of fiber shortening
• decreased ejection fractions at 10 and 24 weeks of age
• myocardial hypertrophy
• systolic dysfunction

growth/size/body
• all chambers of the heart enlarged at 24 weeks of age
• at 24 weeks of age but normal myocardial histology




Genotype
MGI:3584147
ht2
Allelic
Composition
Irx4tm1Jse/Irx4+
Genetic
Background
involves: 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx4tm1Jse mutation (0 available); any Irx4 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• as compared to wild-type controls

growth/size/body
• as compared to wild-type controls

muscle
• as compared to wild-type controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory