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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nhlh1tm1Thbr
targeted mutation 1, Thomas Braun
MGI:2180862
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nhlh1tm1Thbr/Nhlh1tm1Thbr
Nhlh2tm1Thbr/Nhlh2tm1Thbr 		involves: 129S4/SvJae MGI:3057323


Genotype
MGI:3057323
cx1
Allelic
Composition		 Nhlh1tm1Thbr/Nhlh1tm1Thbr
Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh1tm1Thbr mutation (0 available); any Nhlh1 mutation (15 available)
Nhlh2tm1Thbr mutation (0 available); any Nhlh2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron morphology ( J:93303 )
• at E14.5, 16.5 and E18.5 a 30%, 35%, and 73% reduction, respectively, in gonadotropin releasing hormone-positive neurons is seen, however initial proliferation of these neurons is normal
• an almost complete absence of the projecting axons of these neurons in the median eminence is also seen
decreased neuron number ( J:93303 )
• at E14.5, 16.5 and E18.5 a 30%, 35%, and 73% reduction, respectively, in gonadotropin releasing hormone-positive neurons is seen, however initial proliferation of these neurons is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory