Phenotypes associated with this allele

• Allele Symbol: Cenpc1^tm1Khac
• Allele Name: targeted mutation 1, K H Andy Choo
• Allele ID: MGI:2180846
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cenpc1^tm1Khac/Cenpc1^tm1Khac	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2662549

Genotype
MGI:2662549

hm1

• Allelic Composition: Cenpc1^tm1Khac/Cenpc1^tm1Khac
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:45656 )

• mutant embryos die between E3.5 and E8.5, however the exact stage of death is not defined

cellular

abnormal cell nucleus morphology ( J:45656 )

• embryos exhibit irregular sized nuclei and micronuclei

abnormal chromosome morphology ( J:45656 )

• mitotic chromosomes display a scattered and often highly condensed configuration and do not segregate in an ordered fashion

abnormal mitosis ( J:45656 )

• mitotic disarray, with abnormal progression from metaphase to anaphase during the morula stage

embryo

embryonic growth retardation ( J:45656 )

• 80% of E3.5 embryos are delayed in their development or less healthy

growth/size/body

embryonic growth retardation ( J:45656 )

• 80% of E3.5 embryos are delayed in their development or less healthy