About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cebpgtm1Aki
targeted mutation 1, Shizuo Akira
MGI:2180824
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cebpgtm1Aki/Cebpgtm1Aki involves: 129P2/OlaHsd MGI:2662540


Genotype
MGI:2662540
hm1
Allelic
Composition		 Cebpgtm1Aki/Cebpgtm1Aki
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpgtm1Aki mutation (0 available); any Cebpg mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:58801 )
• only 11% of animals survive past 60 hours after birth

immune system
abnormal NK cell physiology ( J:58801 )
• natural killer cells from newborns exhibit impaired IFN-gamma production when stimulated with IL-12 plus IL-18
impaired natural killer cell mediated cytotoxicity ( J:58801 )
• IL-15 induced natural killer cells generated from mutant spleens show impaired cytotoxic activity against YAC-1 cells

respiratory system
overexpanded pulmonary alveolus ( J:58801 )
• at 24 hours after birth, mutants exhibit emphysematous changes in the lungs

hematopoietic system
abnormal NK cell physiology ( J:58801 )
• natural killer cells from newborns exhibit impaired IFN-gamma production when stimulated with IL-12 plus IL-18
impaired natural killer cell mediated cytotoxicity ( J:58801 )
• IL-15 induced natural killer cells generated from mutant spleens show impaired cytotoxic activity against YAC-1 cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory