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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx21+
wild type
MGI:2180788
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tbx21tm1Glm/Tbx21+ involves: 129S6/SvEvTac * C57BL/6 MGI:2180790
ht2
 		Tbx21tm1Srnr/Tbx21+ involves: C57BL/6 MGI:3687961
cn3
 		Tbx21tm2Srnr/Tbx21+
Tg(Cd4-cre)1Cwi/0 		involves: 129 * C57BL/6 * DBA/2 MGI:5140536


Genotype
MGI:2180790
ht1
Allelic
Composition		 Tbx21tm1Glm/Tbx21+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx21tm1Glm mutation (2 available); any Tbx21 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T helper 1 cell number ( J:73833 )
• only 42% of CD4 T cells produce high levels of Ifng compared to wild-type
abnormal NK cell physiology ( J:73833 )
• splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type

immune system
decreased T helper 1 cell number ( J:73833 )
• only 42% of CD4 T cells produce high levels of Ifng compared to wild-type
abnormal NK cell physiology ( J:73833 )
• splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type
abnormal cytokine level ( J:73833 )
• increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type
abnormal interleukin level ( J:73832 )
• increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do
abnormal tumor necrosis factor level ( J:73832 )
• increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type

respiratory system
abnormal respiratory system morphology ( J:73832 )
• mice show an increase in thickness of subbasement collagen layer of the airways, with an increased numbers of bronchial myofibroblast
increased airway responsiveness ( J:73832 )
• 4-5 week old homozygous mice exhibit airway hyperresponsiveness (AHR) to methacholine challenge, in the absence of prior immunologic sensitization; mice are more responsive without allergen challenge than wild-type mice following antigen challenge

homeostasis/metabolism
abnormal cytokine level ( J:73833 )
• increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type
abnormal interleukin level ( J:73832 )
• increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do
abnormal tumor necrosis factor level ( J:73832 )
• increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
asthma DOID:2841 OMIM:600807
 J:73832




Genotype
MGI:3687961
ht2
Allelic
Composition		 Tbx21tm1Srnr/Tbx21+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx21tm1Srnr mutation (0 available); any Tbx21 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:112679 )
• partial loss of natural killer cells
absent NK T cells ( J:112679 )
• lack most NK-T cells

hematopoietic system
decreased NK cell number ( J:112679 )
• partial loss of natural killer cells
absent NK T cells ( J:112679 )
• lack most NK-T cells




Genotype
MGI:5140536
cn3
Allelic
Composition		 Tbx21tm2Srnr/Tbx21+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx21tm2Srnr mutation (1 available); any Tbx21 mutation (39 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:174315 )
• 30 days after LCMV infection, mice exhibit fewer antigen-specific CD8+ T cells in the bone marrow compared with wild-type mice
increased susceptibility to Riboviria infection ( J:174315 )
• LCMV-infected mice exhibit decreased antigen-specific CD8+ T cells and increased viral load in the blood after 60 days compared with wild-type mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:174315 )
• 30 days after LCMV infection, mice exhibit fewer antigen-specific CD8+ T cells in the bone marrow compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory