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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mst1rtm1Sjd
targeted mutation 1, Sandra J F Degen
MGI:2180761
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mst1rtm1Sjd/Mst1rtm1Sjd either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss) MGI:3027716
ht2
 		Mst1rtm1Sjd/Mst1r+ either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss) MGI:3027717


Genotype
MGI:3027716
hm1
Allelic
Composition		 Mst1rtm1Sjd/Mst1rtm1Sjd
Genetic
Background		 either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mst1rtm1Sjd mutation (0 available); any Mst1r mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3027717
ht2
Allelic
Composition		 Mst1rtm1Sjd/Mst1r+
Genetic
Background		 either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mst1rtm1Sjd mutation (0 available); any Mst1r mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:54903 )
• reduced peritoneal macrophage activation, assessed by morphological changes, after stimulation with hepatocyte growth factor
increased susceptibility to bacterial infection ( J:54903 )
• more susceptible to LPS-induced death than littermate controls

hematopoietic system
abnormal macrophage physiology ( J:54903 )
• reduced peritoneal macrophage activation, assessed by morphological changes, after stimulation with hepatocyte growth factor




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory