Phenotypes associated with this allele

• Allele Symbol: Ctla4^tm1Mak
• Allele Name: targeted mutation 1, Tak W Mak
• Allele ID: MGI:2180669
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctla4^tm1Mak/Ctla4^tm1Mak	involves: 129P2/OlaHsd * BALB/c	MGI:3812321

Genotype
MGI:3812321

hm1

• Allelic Composition: Ctla4^tm1Mak/Ctla4^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:140085 )

• mice become moribund around 21 days of age due to autoimmune disease

immune system

increased interferon-gamma secretion ( J:140085 )

• there is an increased frequency of IFN-gamma producing Foxp3^- CD4⁺ T cells in both spleen and lymph nodes

increased interleukin-17 secretion ( J:140085 )

• there is an increased frequency of IL-17 producing Foxp3^- CD4⁺ T cells in both spleen and lymph nodes

increased interleukin-2 secretion ( J:140085 )

• there is an increased frequency of IL-2 producing Foxp3^- CD4⁺ T cells in both spleen and lymph nodes

increased interleukin-4 secretion ( J:140085 )

• there is an increased frequency of IL-4 producing Foxp3^- CD4⁺ T cells in both spleen and lymph nodes