Phenotypes associated with this allele

• Allele Symbol: Ccna2^tm1Sot
• Allele Name: targeted mutation 1, Joelle Sobczak-Thepot
• Allele ID: MGI:2180634
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccna2^tm1Sot/Ccna2^tm1Sot	involves: 129P2/OlaHsd * BALB/c	MGI:5810075

Genotype
MGI:5810075

hm1

• Allelic Composition: Ccna2^tm1Sot/Ccna2^tm1Sot
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:37426 )

• homozygous null embryos were able to survive until 5.5 dpc

embryo

abnormal embryo development ( J:63193 )

• RT-PCR analysis revealed that, by the blastocyst stage, maternal cyclin A2 mRNA was no longer detectable in homozygous null embryos

• maternally derived stocks of cyclin A2 mRNA persisted in the fertilized oocyte through the first mitosis and were then degraded at the late two-cell stage, concurrent with the activation of the zygotic genome

embryonic growth arrest ( J:37426 )

• abnormal or homozygous null embryos ceased development shortly after implantation