Phenotypes associated with this allele

• Allele Symbol: Ckmt2^tm1Bew
• Allele Name: targeted mutation 1, Be Wieringa
• Allele ID: MGI:2180507
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ckmt2^tm1Bew/Ckmt2^tm1Bew	involves: 129P2/OlaHsd * C57BL/6	MGI:3620567
cx2	Ckm^tm1Bew/Ckm^tm1Bew Ckmt2^tm1Bew/Ckmt2^tm1Bew	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:3620566

Genotype
MGI:3620567

hm1

• Allelic Composition: Ckmt2^tm1Bew/Ckmt2^tm1Bew
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:76886 )

N • contractile performance of muscles normal as is gross appearance, behavior, and fertility

heart left ventricle hypertrophy ( J:101961 )

• left ventricular mass increased 73%

cardiovascular system

abnormal cardiovascular system morphology ( J:101961 )

heart left ventricle hypertrophy ( J:101961 )

• left ventricular mass increased 73%

dilated heart left ventricle ( J:101961 )

• increased by about 30%

abnormal cardiovascular system physiology ( J:101961 )

increased cardiac stroke volume ( J:101961 )

decreased systemic arterial systolic blood pressure ( J:101961 )

growth/size/body

heart left ventricle hypertrophy ( J:101961 )

• left ventricular mass increased 73%

Genotype
MGI:3620566

cx2

• Allelic Composition: Ckm^tm1Bew/Ckm^tm1Bew; Ckmt2^tm1Bew/Ckmt2^tm1Bew
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

growth/size/body

heart left ventricle hypertrophy ( J:101961 )

• left ventricular mass increased 64%

• no increased hypertrophy resulting from infarction

decreased body weight ( J:106327 )

• reduced body mass

muscle

heart left ventricle hypertrophy ( J:101961 )

• left ventricular mass increased 64%

• no increased hypertrophy resulting from infarction

decreased skeletal muscle mass ( J:106327 )

• dorsal flexor mass about 20% lower than controls

abnormal muscle physiology ( J:106327 )

• resting muscle ATP concentration lower than normal

impaired skeletal muscle contractility ( J:106327 )

• dorsal flexor slower to build up maximal torque

• maximal torque lower than normal

cardiovascular system

heart left ventricle hypertrophy ( J:101961 )

• left ventricular mass increased 64%

• no increased hypertrophy resulting from infarction

dilated heart left ventricle ( J:101961 )

• increased by about 30%

increased cardiac stroke volume ( J:101961 )