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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		exma
exencephaly and severe microphthalmia/anophthalmia
MGI:2180503
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		exma/exma+ FVB/N-exma MGI:2429431
ot2
 		exma/Y FVB/N-exma MGI:2429428


Genotype
MGI:2429431
ht1
Allelic
Composition		 exma/exma+
Genetic
Background		 FVB/N-exma
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
irregular coat pigmentation ( J:76080 )
• patchy coat pigmentation

behavior/neurological

craniofacial
abnormal cranium morphology ( J:76080 )
• observed in embryos

skeleton
abnormal cranium morphology ( J:76080 )
• observed in embryos

vision/eye
microphthalmia ( J:76080 )
• described as occasional
anophthalmia ( J:76080 )
• observed in 8% of embryos age E9.5- E18.5

nervous system
exencephaly ( J:76080 )
• observed in 8% of embryos age E9.5- E18.5

integument
irregular coat pigmentation ( J:76080 )
• patchy coat pigmentation




Genotype
MGI:2429428
ot2
Allelic
Composition		 exma/Y
Genetic
Background		 FVB/N-exma
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:76080 )
• no transgenic males survive beyond birth

craniofacial
abnormal craniofacial morphology ( J:76080 )
• males were described as showing foreshortened craniofacial features

embryo
decreased embryo size ( J:76080 )
• male embryos were typically smaller than normal littermates

growth/size/body
decreased embryo size ( J:76080 )
• male embryos were typically smaller than normal littermates

vision/eye
anophthalmia ( J:76080 )
• observed in 83% of embryos age E9.5- E18.5

nervous system
abnormal forebrain morphology ( J:76080 )
• disorganized forebrain
exencephaly ( J:76080 )
• observed in 83% of embryos age E9.5- E18.5
• cranial closure defects extended to a level caudal to the external ear indicating that in addition to forebrain and midbrain, the hindbrain neural folds failed to close normally




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory