Phenotypes associated with this allele

• Allele Symbol: Il5ra^tm1Ktk
• Allele Name: targeted mutation 1, Kiyoshi Takatsu
• Allele ID: MGI:2180501
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il5ra^tm1Ktk/Il5ra^tm1Ktk	B6.129P2-Il5ra^tm1Ktk	MGI:3584501
hm2	Il5ra^tm1Ktk/Il5ra^tm1Ktk	involves: 129P2/OlaHsd	MGI:5312104
hm3	Il5ra^tm1Ktk/Il5ra^tm1Ktk	involves: 129P2/OlaHsd * C57BL/6	MGI:3584500
cx4	Il5ra^tm1Ktk/Il5ra^tm1Ktk Lyn^tm1Tya/Lyn^tm1Tya	involves: 129P2/OlaHsd * C57BL/6	MGI:3584502

Genotype
MGI:3584501

hm1

• Allelic Composition: Il5ra^tm1Ktk/Il5ra^tm1Ktk
• Genetic Background: B6.129P2-Il5ra^tm1Ktk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell proliferation ( J:89849 )

• lower proliferative response after stimulation

abnormal B-1 B cell morphology ( J:89849 )

• reduced number and size of B1 cells

decreased B-1 B cell number ( J:89849 )

decreased IgA level ( J:89849 )

• Background Sensitivity: defective production reported here but not seen on a mixed background

decreased IgG1 level ( J:89849 )

decreased IgG3 level ( J:89849 )

decreased IgM level ( J:89849 )

hematopoietic system

decreased B cell proliferation ( J:89849 )

• lower proliferative response after stimulation

abnormal B-1 B cell morphology ( J:89849 )

• reduced number and size of B1 cells

decreased B-1 B cell number ( J:89849 )

decreased IgA level ( J:89849 )

• Background Sensitivity: defective production reported here but not seen on a mixed background

decreased IgG1 level ( J:89849 )

decreased IgG3 level ( J:89849 )

decreased IgM level ( J:89849 )

cellular

decreased B cell proliferation ( J:89849 )

• lower proliferative response after stimulation

Genotype
MGI:5312104

hm2

• Allelic Composition: Il5ra^tm1Ktk/Il5ra^tm1Ktk
• Genetic Background: involves: 129P2/OlaHsd

neoplasm

increased metastatic potential ( J:180790 )

• mice injected with B16F10 melanoma cells exhibit increased nodule formation compared with wild-type mice

Genotype
MGI:3584500

hm3

• Allelic Composition: Il5ra^tm1Ktk/Il5ra^tm1Ktk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

abnormal lymphopoiesis ( J:33140 )

abnormal B cell differentiation ( J:33140 )

• reduced numbers of nucleated cells in the peritoneal cavity at 6-8 weeks of age

abnormal T cell differentiation ( J:33140 )

• reduced number of cells expressing T cell receptor at 3 weeks of age but normal numbers later

abnormal eosinophil cell number ( J:33140 )

• slightly reduced proportion of eosinophiles

decreased CD4-positive, alpha-beta T cell number ( J:33140 )

• reduced number of cells expressing Cd4(+) at 3 weeks of age but normal numbers later

abnormal immune system physiology ( J:33140 )

decreased immunoglobulin level ( J:33140 )

decreased IgA level ( J:33140 )

• Background Sensitivity: normal levels seen on a mixed background as opposed to the C57BL/6 background

decreased IgG3 level ( J:33140 )

• IgG3 levels 1/3 normal

decreased IgM level ( J:33140 )

• half normal

increased susceptibility to parasitic infection ( J:33140 )

• to Angiostrongylus cantonensis

hematopoietic system

abnormal lymphopoiesis ( J:33140 )

abnormal B cell differentiation ( J:33140 )

• reduced numbers of nucleated cells in the peritoneal cavity at 6-8 weeks of age

abnormal T cell differentiation ( J:33140 )

• reduced number of cells expressing T cell receptor at 3 weeks of age but normal numbers later

abnormal eosinophil cell number ( J:33140 )

• slightly reduced proportion of eosinophiles

decreased CD4-positive, alpha-beta T cell number ( J:33140 )

• reduced number of cells expressing Cd4(+) at 3 weeks of age but normal numbers later

decreased immunoglobulin level ( J:33140 )

decreased IgA level ( J:33140 )

• Background Sensitivity: normal levels seen on a mixed background as opposed to the C57BL/6 background

decreased IgG3 level ( J:33140 )

• IgG3 levels 1/3 normal

decreased IgM level ( J:33140 )

• half normal

Genotype
MGI:3584502

cx4

• Allelic Composition: Il5ra^tm1Ktk/Il5ra^tm1Ktk; Lyn^tm1Tya/Lyn^tm1Tya
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

decreased B-1 B cell number ( J:91089 )

• IgM(+) B1 cells reduced about 35%

increased immunoglobulin level ( J:91089 )

increased IgA level ( J:91089 )

• moderately

increased IgM level ( J:91089 )

• moderately

abnormal immune system organ morphology ( J:91089 )

enlarged spleen ( J:91089 )

abnormal spleen white pulp morphology ( J:91089 )

• large lymphoblast-like cells and reticular cells accumulate in white pulp

abnormal spleen B cell corona morphology ( J:91089 )

• decreased numbers of mature lymphocytes

enlarged lymph nodes ( J:91089 )

• enlarged

increased anti-double stranded DNA antibody level ( J:91089 )

• anti dsDNA autoantibodies elevated

glomerulonephritis ( J:91089 )

renal/urinary system

glomerulonephritis ( J:91089 )

hematopoietic system

enlarged spleen ( J:91089 )

decreased B-1 B cell number ( J:91089 )

• IgM(+) B1 cells reduced about 35%

abnormal spleen white pulp morphology ( J:91089 )

• large lymphoblast-like cells and reticular cells accumulate in white pulp

abnormal spleen B cell corona morphology ( J:91089 )

• decreased numbers of mature lymphocytes

increased immunoglobulin level ( J:91089 )

increased IgA level ( J:91089 )

• moderately

increased IgM level ( J:91089 )

• moderately

growth/size/body

enlarged spleen ( J:91089 )