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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il5ratm1Ktk
targeted mutation 1, Kiyoshi Takatsu
MGI:2180501
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il5ratm1Ktk/Il5ratm1Ktk B6.129P2-Il5ratm1Ktk MGI:3584501
hm2
 		Il5ratm1Ktk/Il5ratm1Ktk involves: 129P2/OlaHsd MGI:5312104
hm3
 		Il5ratm1Ktk/Il5ratm1Ktk involves: 129P2/OlaHsd * C57BL/6 MGI:3584500
cx4
 		Il5ratm1Ktk/Il5ratm1Ktk
Lyntm1Tya/Lyntm1Tya 		involves: 129P2/OlaHsd * C57BL/6 MGI:3584502


Genotype
MGI:3584501
hm1
Allelic
Composition		 Il5ratm1Ktk/Il5ratm1Ktk
Genetic
Background		 B6.129P2-Il5ratm1Ktk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il5ratm1Ktk mutation (2 available); any Il5ra mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:89849 )
• lower proliferative response after stimulation
abnormal B-1 B cell morphology ( J:89849 )
• reduced number and size of B1 cells
decreased IgA level ( J:89849 )
• Background Sensitivity: defective production retorted here but not seen on a mixed background

hematopoietic system
decreased B cell proliferation ( J:89849 )
• lower proliferative response after stimulation
abnormal B-1 B cell morphology ( J:89849 )
• reduced number and size of B1 cells
decreased IgA level ( J:89849 )
• Background Sensitivity: defective production retorted here but not seen on a mixed background

cellular
decreased B cell proliferation ( J:89849 )
• lower proliferative response after stimulation




Genotype
MGI:5312104
hm2
Allelic
Composition		 Il5ratm1Ktk/Il5ratm1Ktk
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il5ratm1Ktk mutation (2 available); any Il5ra mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased metastatic potential ( J:180790 )
• mice injected with B16F10 melanoma cells exhibit increased nodule formation compared with wild-type mice




Genotype
MGI:3584500
hm3
Allelic
Composition		 Il5ratm1Ktk/Il5ratm1Ktk
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il5ratm1Ktk mutation (2 available); any Il5ra mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:33140 )
• reduced numbers of nucleated cells in the peritoneal cavity at 6-8 weeks of age
abnormal T cell differentiation ( J:33140 )
• reduced number of cells expressing T cell receptor at 3 weeks of age but normal numbers later
abnormal eosinophil cell number ( J:33140 )
• slightly reduced proportion of eosinophiles
decreased CD4-positive, alpha-beta T cell number ( J:33140 )
• reduced number of cells expressing Cd4(+) at 3 weeks of age but normal numbers later
decreased IgA level ( J:33140 )
• Background Sensitivity: normal levels seen on a mixed background as opposed to the C57BL/6 background
decreased IgG3 level ( J:33140 )
• IgG3 levels 1/3 normal
decreased IgM level ( J:33140 )
• half normal
increased susceptibility to parasitic infection ( J:33140 )
• to Angiostrongylus cantonensis

hematopoietic system
abnormal B cell differentiation ( J:33140 )
• reduced numbers of nucleated cells in the peritoneal cavity at 6-8 weeks of age
abnormal T cell differentiation ( J:33140 )
• reduced number of cells expressing T cell receptor at 3 weeks of age but normal numbers later
abnormal eosinophil cell number ( J:33140 )
• slightly reduced proportion of eosinophiles
decreased CD4-positive, alpha-beta T cell number ( J:33140 )
• reduced number of cells expressing Cd4(+) at 3 weeks of age but normal numbers later
decreased IgA level ( J:33140 )
• Background Sensitivity: normal levels seen on a mixed background as opposed to the C57BL/6 background
decreased IgG3 level ( J:33140 )
• IgG3 levels 1/3 normal
decreased IgM level ( J:33140 )
• half normal




Genotype
MGI:3584502
cx4
Allelic
Composition		 Il5ratm1Ktk/Il5ratm1Ktk
Lyntm1Tya/Lyntm1Tya
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il5ratm1Ktk mutation (2 available); any Il5ra mutation (36 available)
Lyntm1Tya mutation (1 available); any Lyn mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1 B cell number ( J:91089 )
• IgM(+) B1 cells reduced about 35%
increased IgA level ( J:91089 )
• moderately
increased IgM level ( J:91089 )
• moderately
abnormal spleen white pulp morphology ( J:91089 )
• large lymphoblast-like cells and reticular cells accumulate in white pulp
abnormal spleen B cell corona morphology ( J:91089 )
• decreased numbers of mature lymphocytes
enlarged lymph nodes ( J:91089 )
• enlarged
increased anti-double stranded DNA antibody level ( J:91089 )
• anti dsDNA autoantibodies elevated

renal/urinary system

hematopoietic system
decreased B-1 B cell number ( J:91089 )
• IgM(+) B1 cells reduced about 35%
abnormal spleen white pulp morphology ( J:91089 )
• large lymphoblast-like cells and reticular cells accumulate in white pulp
abnormal spleen B cell corona morphology ( J:91089 )
• decreased numbers of mature lymphocytes
increased IgA level ( J:91089 )
• moderately
increased IgM level ( J:91089 )
• moderately

growth/size/body
enlarged spleen ( J:91089 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory