Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe40tm1Tan mutation
(0 available);
any
Bhlhe40 mutation
(50 available)
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behavior/neurological
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• when mice are subjected to light pulses following constant darkness, the transition phase is prolonged compared to in wild-type mice
• following an 8 hours light dark cycle delay (experimental jet lag), mice exhibit a delayed behavioral re-entrainment compared to wild-type mice
• however, the photic phase response curve and rhythmicity of wheel running during light dark and dark dark phases is normal
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Allelic
Composition |
Bhlhe40tm1Tan/Bhlhe40tm1Tan
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Genetic
Background |
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe40tm1Tan mutation
(0 available);
any
Bhlhe40 mutation
(50 available)
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immune system
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• spontaneous activation of B and T cells
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• naive CD4+ T cells cultured under both TH1 and TH2 polarizing conditions produce less IFN-gamma and IL-4, indicating a defective differentiation into effector cells
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• 18-fold increase in double-negative thymocyte population at 6-8 months of age
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• 95% decrease in double-positive thymocytes at 6-8 months of age
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• 2- to 4-fold increase in mature CD4+ single-positive cells
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• 2- to 4-fold increase in mature CD8+ single-positive cells
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• aging mice exhibit increased germinal centers in lymph nodes
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• aging mutants show lymph node hyperplasia
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• hyporesponsive immune system
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• elevation of IgE in lymphoid tissue
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• elevation of IgG1 in lymphoid tissue
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• effector CD4+ T cells from 8-10 week old mutants exhibit greater resistance to antigen induced cell death (AICD)
• restimulation of activated CD4+ T cells in the presence of activated B cells results in an increase in B cell survival, suggesting that CD4+ T cells cannot eliminate activated B cells efficiently
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• draining lymph node cells from KLH immunized mutants proliferate at a lower rate than wild-type cells and show a reduction in IL-2 and TH1-type cytokine production
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• CD4+ T cells proiferate less efficiently than wild-type cells upon stimulation with a low dose of anti-CD3 and anti-CD28 antibodies
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• activated CD4+ T cells show a 70% reduction in IL-2 production
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• mutants develop a chronic systemic lupus-like autoimmune disease with age
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• circulating autoreactive nuclear antibodies are present in aging mutants
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hematopoietic system
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• naive CD4+ T cells cultured under both TH1 and TH2 polarizing conditions produce less IFN-gamma and IL-4, indicating a defective differentiation into effector cells
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• 18-fold increase in double-negative thymocyte population at 6-8 months of age
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• 95% decrease in double-positive thymocytes at 6-8 months of age
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• 2- to 4-fold increase in mature CD4+ single-positive cells
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• 2- to 4-fold increase in mature CD8+ single-positive cells
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• elevation of IgE in lymphoid tissue
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• elevation of IgG1 in lymphoid tissue
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• effector CD4+ T cells from 8-10 week old mutants exhibit greater resistance to antigen induced cell death (AICD)
• restimulation of activated CD4+ T cells in the presence of activated B cells results in an increase in B cell survival, suggesting that CD4+ T cells cannot eliminate activated B cells efficiently
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• draining lymph node cells from KLH immunized mutants proliferate at a lower rate than wild-type cells and show a reduction in IL-2 and TH1-type cytokine production
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• CD4+ T cells proiferate less efficiently than wild-type cells upon stimulation with a low dose of anti-CD3 and anti-CD28 antibodies
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renal/urinary system
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• aging mice exhibit hypercellularity and proteinaceous deposits in glomeruli
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endocrine/exocrine glands
growth/size/body
cellular
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• CD4+ T cells proiferate less efficiently than wild-type cells upon stimulation with a low dose of anti-CD3 and anti-CD28 antibodies
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe40tm1Tan mutation
(0 available);
any
Bhlhe40 mutation
(50 available)
Bhlhe41tm1Mjro mutation
(1 available);
any
Bhlhe41 mutation
(12 available)
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behavior/neurological
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• free-running period length in constant darkness following light dark entrainment is lengthened compared to in wild-type mice
• however, rhythmicity of wheel running during light dark and dark dark phases is normal
|
|
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• phase shift responses are lengthened
• however, the photic phase response curve is normal
• following an 8 hours light dark cycle delay (experimental jet lag), mice exhibit significant delayed behavioral re-entrainment compared to wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe40tm1Tan mutation
(0 available);
any
Bhlhe40 mutation
(50 available)
Bhlhe41tm1Mjro mutation
(1 available);
any
Bhlhe41 mutation
(12 available)
|
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behavior/neurological
|
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• free-running period length in constant darkness following light dark entrainment is lengthened compared to in wild-type mice
• however, rhythmicity of wheel running during light dark and dark dark phases is normal
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• following an 8 hours light dark cycle delay (experimental jet lag), mice exhibit significant delayed behavioral re-entrainment compared to wild-type mice that is not greater than in Bhlhb2tm1Tan homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe40tm1Tan mutation
(0 available);
any
Bhlhe40 mutation
(50 available)
Bhlhe41tm1Mjro mutation
(1 available);
any
Bhlhe41 mutation
(12 available)
|
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behavior/neurological
|
|
• free-running period length in constant darkness following light dark entrainment is lengthened compared to in wild-type mice
• however, rhythmicity of wheel running during light dark and dark dark phases is normal
|
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• following an 8 hours light dark cycle delay (experimental jet lag), mice exhibit significant delayed behavioral re-entrainment compared to wild-type mice that is not greater than in Bhlhb2tm1Tan homozygotes
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Analysis Tools