Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npas2tm1Slm mutation
(1 available);
any
Npas2 mutation
(45 available)
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cardiovascular system
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• particularly during the light dark transition
• however, diurnal rhythmicity is maintained
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• particularly during the light dark transition
• diurnal rhythmicity is maintained; however, the acrophase (time of peak) is delayed
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npas2tm1Slm mutation
(1 available);
any
Npas2 mutation
(45 available)
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cardiovascular system
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• basaline blood flow is decreased compared to in wild-type mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npas2tm1Slm mutation
(1 available);
any
Npas2 mutation
(45 available)
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behavior/neurological
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• in an adapted CCF assay, mutants show decreased freezing behavior in an environment where smell and appearance of the cage is novel, but the texture of the cage flooring is identical to that used in training; the cued stimulus used in this 'novel' environment facilitates recall in both mutant and wild-type mice (freezing behavior 45% vs 62% in wild-type)
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• mutants freeze less often than wild-type in the 24-hour contextual arm of a CCF assay (35% vs 50%), but no differences are seen in the 0.5 hour arm of the assay
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• in the 24-hour cued arm of the CCF assay, mutants exhibit a significant deficit relative to wild-type littermates (40% vs 50%); freezing behavior before the auditory cue is similar between mutant and wild-type
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• sleep time is reduced in mutants; initial sustained period of wakefulness in null mice is 7 hours vs 5.9 hours for wild-type
• mice have fewer waking bouts (2.8) than wild-type (3.6) and the average length per waking bout is increased by ~2 hours (237 minutes vs 127 minutes)
• null mice lose ~41 minutes of non REM sleep each day compared to wild-type
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• mice have fewer waking bouts (2.8) than wild-type (3.6) and the average length per waking bout is increased by ~2 hours (237 minutes vs 127 minutes)
• null mice lose ~41 minutes of non REM sleep each day compared to wild-type
• mutant males lag behind female mutants and wild-type mice in recovery of sleep time
• changes in delta frequency range show a 2-fold increase over baseline and was lower in mutants in the lower delta range; ratio of EEG power in fast and slow delta power is generally smaller in mutants and the ratio transiently increased during non REM sleep after prolonged periods of wakefulness more in mutants
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• female mutants exhibit a higher number of transitions from non REM sleep to REM sleep compared to males
• rhythmic EEG activity is altered in mutants
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nervous system
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• during sleep, changes in delta frequency range show a 2-fold increase over baseline and was lower in mutants in the lower delta range; ratio of EEG power in fast and slow delta power is generally smaller in mutants and the ratio transiently increased during non REM sleep after prolonged periods of wakefulness more in mutants
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Analysis Tools