All Phenotypes Stx4a<tm1Jpes> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Stx4a^tm1Jpes
targeted mutation 1, Jeffrey E Pessin
MGI:2180164

Summary

2 genotypes

Allelic Composition	Stx4a^tm1Jpes/Stx4a^tm1Jpes
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx4a^tm1Jpes mutation (1 available); any Stx4a mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• homozygous embryos die before E7.5

Allelic Composition	Stx4a^tm1Jpes/Stx4a⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx4a^tm1Jpes mutation (1 available); any Stx4a mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

• measured in fasting serum of heterozygous mice

impaired glucose tolerance ( J:69598 )

• heterozygous mice exhibit a reduced ability to clear glucose from the peripheral circulation

insulin resistance ( J:69598 )

• skeletal muscle of heterozygous mice exhibits an impaired ability to transport glucose; adipose tissue and liver were unaffected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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