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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Inhba+
wild type
MGI:2180162
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Inhbatm1Zuk/Inhba+ B6.129S7-Inhbatm1Zuk MGI:5319780
cx2
 		Inhbatm1Zuk/Inhba+
Inhbbtm1Jae/Inhbbtm1Jae 		involves: 129S4/SvJae * 129S7/SvEvBrd MGI:3758890


Genotype
MGI:5319780
ht1
Allelic
Composition		 Inhbatm1Zuk/Inhba+
Genetic
Background		 B6.129S7-Inhbatm1Zuk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhbatm1Zuk mutation (2 available); any Inhba mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
increased quadriceps weight ( J:182827 )
• in males and females
increased gastrocnemius weight ( J:182827 )
• in males and females
increased skeletal muscle weight ( J:182827 )
• increased triceps weight in males and females
abnormal pectoral muscle morphology ( J:182827 )
• increased weight in males and females

growth/size/body
increased body weight ( J:182827 )
• in males

limbs/digits/tail
increased quadriceps weight ( J:182827 )
• in males and females
increased gastrocnemius weight ( J:182827 )
• in males and females




Genotype
MGI:3758890
cx2
Allelic
Composition		 Inhbatm1Zuk/Inhba+
Inhbbtm1Jae/Inhbbtm1Jae
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhbatm1Zuk mutation (2 available); any Inhba mutation (29 available)
Inhbbtm1Jae mutation (3 available); any Inhbb mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased corpora lutea number ( J:125354 )
• beginning at 3 months of age and readily identifiable by 8 months of age, the number of corpus luteums is increased relative to Inhbatm1Zuk/Inhbatm3Zuk mice
• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhbatm1Zuk/Inhbatm3Zuk mice
female infertility ( J:125354 )
• 3 of 11 females are infertile
reduced female fertility ( J:125354 )
• the number of litters produced by females is reduced 43% (0.08+/-0.08 litters per month compared 0.89+/-0.04 litters per month in Inhbatm1Zuk/Inhbatm3Zuk mice)
• however, there is no difference in the number of oocytes produced upon superovulation compared to Inhbatm1Zuk/Inhbatm3Zuk females
decreased litter size ( J:125354 )
• the number of pups per litter is decreased 33% relative (.80+/-0.49 pups per litter compared to 7.78+/-0.48 pups per litter in Inhbatm1Zuk/Inhbatm3Zuk mice)

endocrine/exocrine glands
increased corpora lutea number ( J:125354 )
• beginning at 3 months of age and readily identifiable by 8 months of age, the number of corpus luteums is increased relative to Inhbatm1Zuk/Inhbatm3Zuk mice
• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhbatm1Zuk/Inhbatm3Zuk mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory