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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Alas2tm1Mym
targeted mutation 1, Masayuki Yamamoto
MGI:2180151
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Alas2tm1Mym/Y involves: 129P2/OlaHsd * C57BL/6 MGI:2654874


Genotype
MGI:2654874
ot1
Allelic
Composition		 Alas2tm1Mym/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alas2tm1Mym mutation (0 available); any Alas2 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
abnormal embryonic hematopoiesis ( J:58508 )
• arrested primitive hematopoiesis
abnormal embryonic erythropoiesis ( J:58508 )
• erythroid differentiation is arrested
anemia ( J:58508 )
• embryos are severely anemic at E11
pancytopenia ( J:58508 )
• number of circulating blood cells is decreased in E10.5 mutants

embryo
abnormal embryonic hematopoiesis ( J:58508 )
• arrested primitive hematopoiesis
abnormal embryonic erythropoiesis ( J:58508 )
• erythroid differentiation is arrested

homeostasis/metabolism
abnormal iron level ( J:58508 )
• severe accumulation of iron in the cytoplasm of circulating blood cells of E9.5 and E10.5 mutants

integument
pallor ( J:58508 )
• embryos are pale at E11.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory