Analysis Tools
mortality/aging
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• though most mice die by P2, surviving mice could be weaned and survive longer than 6 months if raised without postnatal food competition from normal littermates
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• most mice die by P2 with no milk in their stomachs
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reproductive system
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• as indicated by preliminary results
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nervous system
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• despite abnormal sensory ganglia, spinal motor neurons develop normally
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• mice exhibit severe loss of neuronal cells in the sensory ganglia
• fewer Ntrk3+ neurons are present in the sensory ganglia as compared to in wild-type mice
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• at E15, E17 and P1, the volume of the trigeminal ganglia is reduced to 30% to 35% of wild-type
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• at E17, the volume of the dorsal ganglia is reduced to less than 50% of wild-type
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behavior/neurological
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• mice die by P2 with no milk in their stomachs
• surviving mice exhibit poor suckling reflex
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• surviving mice exhibit poor suckling reflex
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• beginning 1 week after birth, mice exhibit ataxia and by 3 weeks of age they cannot coordinate the movement necessary for walking
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growth/size/body
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• likely due to malnutrition caused by the poor suckling reflex
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muscle
