Phenotypes associated with this allele

• Allele Symbol: S100a8^tm1Hume
• Allele Name: targeted mutation 1, David A Hume
• Allele ID: MGI:2179780
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	S100a8^tm1Hume/S100a8^tm1Hume	involves: 129S1/Sv * 129X1/SvJ	MGI:2181798

Genotype
MGI:2181798

hm1

• Allelic Composition: S100a8^tm1Hume/S100a8^tm1Hume
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:56750 )

• embryos die approximately E8-E8.5; all homozygous embryos are resorbed by E9.5

embryo

embryo phenotype ( J:56750 )

N • preimplantation and trophoblast development are normal; further development appears normal until resorption occurs

abnormal embryonic tissue morphology ( J:56750 )

• embryos are infiltrated with maternal cells prior to resorption; decidualization appears normal

abnormal extraembryonic tissue morphology ( J:56750 )

• decidua are infiltrated with maternal cells prior to resorption; decidualization appears normal