About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sv2btm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:2179737
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sv2btm1Sud/Sv2btm1Sud involves: 129P2/OlaHsd * C57BL/6 MGI:2180323
cx2
 		Sv2atm1Sud/Sv2a+
Sv2btm1Sud/Sv2btm1Sud 		involves: 129P2/OlaHsd * C57BL/6 MGI:2180321
cx3
 		Sv2atm1Sud/Sv2atm1Sud
Sv2btm1Sud/Sv2btm1Sud 		involves: 129P2/OlaHsd * C57BL/6 MGI:2180322


Genotype
MGI:2180323
hm1
Allelic
Composition		 Sv2btm1Sud/Sv2btm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2btm1Sud mutation (1 available); any Sv2b mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype

nervous system
nervous system phenotype ( J:59180 )
N
• normal brain morphology




Genotype
MGI:2180321
cx2
Allelic
Composition		 Sv2atm1Sud/Sv2a+
Sv2btm1Sud/Sv2btm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2atm1Sud mutation (1 available); any Sv2a mutation (36 available)
Sv2btm1Sud mutation (1 available); any Sv2b mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:2180322
cx3
Allelic
Composition		 Sv2atm1Sud/Sv2atm1Sud
Sv2btm1Sud/Sv2btm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2atm1Sud mutation (1 available); any Sv2a mutation (36 available)
Sv2btm1Sud mutation (1 available); any Sv2b mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:59180 )
• 50% of animals die in the first few days after birth; the remainder die by P21

behavior/neurological
seizures ( J:59180 )
• age of onset P8; increasing severity and frequency with age

nervous system
nervous system phenotype ( J:59180 )
N
• normal brain morphology
seizures ( J:59180 )
• age of onset P8; increasing severity and frequency with age
decreased synaptic depression ( J:59180 )
• reduced short-term synaptic depression; 3-5 fold increase during repetitive stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory