All Phenotypes Rph3a<tm1Sud> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rph3a^tm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:2179730

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rph3a^tm1Sud/Rph3a^tm1Sud	involves: 129P2/OlaHsd * C57BL/6J	MGI:2179731
cx2	Doc2a^tm1Ytk/Doc2a^tm1Ytk Doc2b^tm1Aljg/Doc2b^tm1Aljg Doc2g^tm1.2Aljg/Doc2g^tm1.2Aljg Rph3a^tm1Sud/Rph3a^tm1Sud Syt7^tm1Sud/Syt7^tm1Sud	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7738542
cx3	Doc2a^tm1Ytk/Doc2a^tm1Ytk Doc2b^tm1Aljg/Doc2b^tm1Aljg Rph3a^tm1Sud/Rph3a^tm1Sud	involves: 129P2/OlaHsd * C57BL/6	MGI:7738541

Allelic Composition	Rph3a^tm1Sud/Rph3a^tm1Sud
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rph3a^tm1Sud mutation (1 available); any Rph3a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:56293 )

Allelic Composition	Doc2a^tm1Ytk/Doc2a^tm1Ytk Doc2b^tm1Aljg/Doc2b^tm1Aljg Doc2g^tm1.2Aljg/Doc2g^tm1.2Aljg Rph3a^tm1Sud/Rph3a^tm1Sud Syt7^tm1Sud/Syt7^tm1Sud
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2a^tm1Ytk mutation (0 available); any Doc2a mutation (18 available)
Doc2b^tm1Aljg mutation (0 available); any Doc2b mutation (22 available)
Doc2g^tm1.2Aljg mutation (0 available); any Doc2g mutation (11 available)
Rph3a^tm1Sud mutation (1 available); any Rph3a mutation (40 available)
Syt7^tm1Sud mutation (1 available); any Syt7 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal synaptic plasticity ( J:317639 )

• short-term plasticity is altered by accentuating short-term depression

abnormal synaptic depression ( J:317639 )

• hippocampal neurons show more pronounced short-term depression

• the deeper short-term depression is not associated with changes in evoked release during burst stimuli

decreased paired-pulse ratio ( J:317639 )

• hippocampal neurons show reduced paired-pulse ratio with a more pronounced short-term depression

• however, spontaneous neurotransmitter release in glutamatergic hippocampal neurons is unaltered

Allelic Composition	Doc2a^tm1Ytk/Doc2a^tm1Ytk Doc2b^tm1Aljg/Doc2b^tm1Aljg Rph3a^tm1Sud/Rph3a^tm1Sud
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal miniature excitatory postsynaptic currents ( J:317639 )

• miniature excitatory postsynaptic current (mEPSC) release rate of hippocampal neurons in network cultures, but not in autapses, is increased indicating increased spontaneous glutamate release

• the normalized mEPSC frequency is increased and the decay is slightly, but significantly, faster

• however, the amplitude and rise time remains unchanged for hippocampal neurons and the frequency and kinetics of mEPSCs in autaptic neurons are unchanged

increased neurotransmitter release ( J:317639 )

• hippocampal neurons show an increase in spontaneous release frequency in network cultures, but not in autapses

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