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Allele Symbol Allele Name Allele ID |
Nfkb2tm1Sbn targeted mutation 1, Ulrich Siebenlist MGI:2179705 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 30 to 60 minutes after exposure to HMGB1, mouse embryonic fibroblasts (MEFs) exhibit modestly blunted migration velocity compared with wild-type mice
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• MEFs exhibit impaired chemotaxis in response to HMGB1 compared with wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following infection with T. gondii, mice exhibit increased mortality compared with wild-type mice
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• TNP-KLH-stimulated mice fail to exhibit antigen-specific class switching unlike similarly treated wild-type mice
• however, class switching in mice treated with TNP-Ficoll is normal
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• the ratio of B to T cells is reduced compared to in wild-type mice
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• B220+ B cells are reduced in the spleen and lymph nodes compared to in wild-type mice
• B cell reduction increased with age regardless of IgM or IgD expression
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• CD3+ T cells are increased in the spleen and lymph nodes compared to in wild-type mice
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• the white pulp is infiltrated with macrophage subpopulations that are normally completely excluded in wild-type mice
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• no metallophillic macrophages are detected in the marginal zone unlike in wild-type mice
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• splenic B cell follicles are decreased compared to in wild-type mice with a ring of B220+ cells surrounding the white pulp within the spleen
• however, when cells are adoptively transferred into Rag null mice can generate normal follicular areas
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• in response to T-dependent antigens
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• fewer marginal zone macrophages are detected in the outer ring of the marginal zone compared to in wild-type mice
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• influenza-challenged mice produce fewer flu-specific IgG2a production compared with similarly treated wild-type mice
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• in TNP-KLH-stimulated mice
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• following infection with T. gondii, mice exhibit increased mortality compared with wild-type mice
|
|
• TNP-KLH-stimulated mice fail to exhibit antigen-specific class switching unlike similarly treated wild-type mice
• however, class switching in mice treated with TNP-Ficoll is normal
|
|
• the ratio of B to T cells is reduced compared to in wild-type mice
|
|
• B220+ B cells are reduced in the spleen and lymph nodes compared to in wild-type mice
• B cell reduction increased with age regardless of IgM or IgD expression
|
|
• CD3+ T cells are increased in the spleen and lymph nodes compared to in wild-type mice
|
|
• the white pulp is infiltrated with macrophage subpopulations that are normally completely excluded in wild-type mice
|
|
• no metallophillic macrophages are detected in the marginal zone unlike in wild-type mice
|
|
• splenic B cell follicles are decreased compared to in wild-type mice with a ring of B220+ cells surrounding the white pulp within the spleen
• however, when cells are adoptively transferred into Rag null mice can generate normal follicular areas
|
|
• in response to T-dependent antigens
|
|
• fewer marginal zone macrophages are detected in the outer ring of the marginal zone compared to in wild-type mice
|
|
• influenza-challenged mice produce fewer flu-specific IgG2a production compared with similarly treated wild-type mice
|
|
• in TNP-KLH-stimulated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die between 3 and 4 weeks
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• osteoclast differentiation is halted prior to TRAP expression
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• B cell developmental block occurs at the immature IgM stage
• the block in B cell development is maintained when cells are adoptively transferred into in Rag1 null mice
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• mice exhibit a higher proportional of granulocytes in the spleen compared to in wild-type mice due to a decrease in other cell types
• however, bone marrow granulocyte numbers are normal
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• fewer M342+ interdigitating dendritic cells are present and are disorganized compared to in wild-type mice
• thymic medullary dendritic cells are reduced in number and disorganized compared to in wild-type mice
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• B220+ B cells in the spleen are decreased 1.3- to 2.6-fold compared to in wild-type mice
• IgM+ B cells are reduced and IgD+ cells are undetected unlike in wild-type mice
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• no T cells are detected in the spleen
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• reduction in dull staining double positive T cells
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• single positive T cells are low in the thymus and undetected in the periphery unlike in wild-type mice
• however, single T cells are produced when transferred into Rag1 null mice
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• no TRAP+ osteoclasts are detected unlike in wild-type mice
• however, no abnormal apoptosis of osteoclasts is detected
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• mice exhibit a higher proportional of macrophages in the spleen compared to in wild-type mice due to a decrease in other cell types
• however, bone marrow macrophage numbers are normal
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• mature macrophage functions are impaired
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• thymic cortical epithelial cells are randomly distributed unlike in wild-type mice
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• medullary epithelial cells are absent
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• 10- to 30-fold fewer cells
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• B220+ B cells are diffusely distributed throughout the spleen with only a few rare T cells and macrophages present throughout the spleen unlike in wild-type mice
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• osteoclast differentiation is halted prior to TRAP expression
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• incisors fail to erupt
• however, adoptive transfer with wild-type liver cells restores tooth eruption by 5 weeks
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• no TRAP+ osteoclasts are detected unlike in wild-type mice
• however, no abnormal apoptosis of osteoclasts is detected
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• long bones are shortened, radio-opaque, and lack proper bone marrow cavities unlike in wild-type mice
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• long bones lack proper bone marrow cavities
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• at 2 to 4 weeks, mice develop osteopetrosis
• however, adoptive transfer with wild-type bone marrow cells rescues osteopetrosis
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• incisors fail to erupt
• however, adoptive transfer with wild-type liver cells restores tooth eruption by 5 weeks
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• within a week of birth
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• incisors fail to erupt
• however, adoptive transfer with wild-type liver cells restores tooth eruption by 5 weeks
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• osteoclast differentiation is halted prior to TRAP expression
|
|
• thymic cortical epithelial cells are randomly distributed unlike in wild-type mice
|
|
• medullary epithelial cells are absent
|
|
• 10- to 30-fold fewer cells
|
|
• B cell developmental block occurs at the immature IgM stage
• the block in B cell development is maintained when cells are adoptively transferred into in Rag1 null mice
|
|
• mice exhibit a higher proportional of granulocytes in the spleen compared to in wild-type mice due to a decrease in other cell types
• however, bone marrow granulocyte numbers are normal
|
|
• fewer M342+ interdigitating dendritic cells are present and are disorganized compared to in wild-type mice
• thymic medullary dendritic cells are reduced in number and disorganized compared to in wild-type mice
|
|
• B220+ B cells in the spleen are decreased 1.3- to 2.6-fold compared to in wild-type mice
• IgM+ B cells are reduced and IgD+ cells are undetected unlike in wild-type mice
|
|
• no T cells are detected in the spleen
|
|
• reduction in dull staining double positive T cells
|
|
• single positive T cells are low in the thymus and undetected in the periphery unlike in wild-type mice
• however, single T cells are produced when transferred into Rag1 null mice
|
|
• no TRAP+ osteoclasts are detected unlike in wild-type mice
• however, no abnormal apoptosis of osteoclasts is detected
|
|
• mice exhibit a higher proportional of macrophages in the spleen compared to in wild-type mice due to a decrease in other cell types
• however, bone marrow macrophage numbers are normal
|
|
• B220+ B cells are diffusely distributed throughout the spleen with only a few rare T cells and macrophages present throughout the spleen unlike in wild-type mice
|
|
• mature macrophage functions are impaired
|
|
• osteoclast differentiation is halted prior to TRAP expression
|
|
• thymic cortical epithelial cells are randomly distributed unlike in wild-type mice
|
|
• medullary epithelial cells are absent
|
|
• 10- to 30-fold fewer cells
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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