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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		RelbTg(H2-K1/GH1)106Bri
transgene insertion 106, Ralph L Brinster
MGI:2179544
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri C57BL/6-RelbTg(H2-K1/GH1)106Bri MGI:2179614
hm2
 		RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri involves: C57BL/6 MGI:4361565
ht3
 		RelbTg(H2-K1/GH1)106Bri/Relb+ involves: C57BL/6 MGI:4361566
cx4
 		Map3k14aly/Map3k14+
RelbTg(H2-K1/GH1)106Bri/Relb+ 		involves: C57BL/6 * C57BL/6J MGI:4361564


Genotype
MGI:2179614
hm1
Allelic
Composition		 RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic
Background		 C57BL/6-RelbTg(H2-K1/GH1)106Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RelbTg(H2-K1/GH1)106Bri mutation (1 available); any Relb mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:76450 )
• mice that survive to weaning die within several months
preweaning lethality, incomplete penetrance ( J:76450 )
• fewer than expected mice survived to weaning (12% compared to the expected 25%)

immune system
absent thymus medulla ( J:23081 , J:76450 )
• the medulla is almost completely absent (J:23081)
• the medulla is almost completely absent (J:76450)
enlarged spleen ( J:76450 )
• spleen is enlarged (3- to 10-fold larger than in wild-type mice) and unusually firm
increased granulocyte number ( J:23081 , J:76450 )
• 23% of total spleen compared to 0.5% in wild-type mice (J:76450)
decreased T cell number ( J:76450 )
• 18% of spleen cells compared to 36% in wild-type mice
• however, the total number of T cells is normal
increased macrophage cell number ( J:23081 , J:76450 )
• 13% to 18% of total spleen compared to 3% to 5% in wild-type mice (J:76450)
abnormal Peyer's patch morphology ( J:76450 )
• Peyer's patch and lymph nodes are extremely difficult to find
abnormal lymph node morphology ( J:76450 )
• Peyer's patch and lymph nodes are extremely difficult to find
abnormal antigen presentation ( J:23081 )
• antigen-presenting function is impaired
increased inflammatory response ( J:23081 , J:76450 )
• mice exhibit severe inflammatory syndrome with mixed granylocyte/monocyte infiltrate in the lung, liver and other tissues (J:23081)
• inflammatory infiltrate is present in the epididymis, pancreas, skeletal muscle and cardiac muscle (J:76450)
glomerulonephritis ( J:76450 )
• in older mice
lung inflammation ( J:76450 )
• infiltrate accumulates in the lung without exudates or pneumonia
skin inflammation ( J:76450 )
• mice exhibit inflammation in the skin of the ear, tail and periorbital regions

growth/size/body
decreased body size ( J:76450 )
• at weaning mice are often smaller than wild-type mice
cachexia ( J:76450 )
• all mice that survive past weaning spontaneously develop wasting syndrome
enlarged spleen ( J:76450 )
• spleen is enlarged (3- to 10-fold larger than in wild-type mice) and unusually firm

respiratory system
lung inflammation ( J:76450 )
• infiltrate accumulates in the lung without exudates or pneumonia
abnormal lung morphology ( J:76450 )
• lungs are mottled

liver/biliary system

renal/urinary system
glomerulonephritis ( J:76450 )
• in older mice

homeostasis/metabolism
skin edema ( J:76450 )
• skin on the tail and eyes becomes edematous

hematopoietic system
absent thymus medulla ( J:23081 , J:76450 )
• the medulla is almost completely absent (J:23081)
• the medulla is almost completely absent (J:76450)
enlarged spleen ( J:76450 )
• spleen is enlarged (3- to 10-fold larger than in wild-type mice) and unusually firm
increased granulocyte number ( J:23081 , J:76450 )
• 23% of total spleen compared to 0.5% in wild-type mice (J:76450)
decreased T cell number ( J:76450 )
• 18% of spleen cells compared to 36% in wild-type mice
• however, the total number of T cells is normal
increased macrophage cell number ( J:23081 , J:76450 )
• 13% to 18% of total spleen compared to 3% to 5% in wild-type mice (J:76450)

integument
skin edema ( J:76450 )
• skin on the tail and eyes becomes edematous
skin inflammation ( J:76450 )
• mice exhibit inflammation in the skin of the ear, tail and periorbital regions
ruffled hair ( J:76450 )
• fur becomes ruffled
hyperkeratosis ( J:76450 )
• in the skin of the ears

endocrine/exocrine glands
absent thymus medulla ( J:23081 , J:76450 )
• the medulla is almost completely absent (J:23081)
• the medulla is almost completely absent (J:76450)

cellular




Genotype
MGI:4361565
hm2
Allelic
Composition		 RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RelbTg(H2-K1/GH1)106Bri mutation (1 available); any Relb mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:120659 )
• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice
decreased circulating interleukin-4 level ( J:120659 )
• serum from alpha-GalCer-treated mice lacks IL4 unlike similarly treated wild-type mice
increased inflammatory response ( J:120659 )
• mice develop multi-organ inflammation unlike wild-type mice

homeostasis/metabolism
decreased circulating interleukin-4 level ( J:120659 )
• serum from alpha-GalCer-treated mice lacks IL4 unlike similarly treated wild-type mice

hematopoietic system
decreased NK T cell number ( J:120659 )
• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice




Genotype
MGI:4361566
ht3
Allelic
Composition		 RelbTg(H2-K1/GH1)106Bri/Relb+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RelbTg(H2-K1/GH1)106Bri mutation (1 available); any Relb mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:120659 )
• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice

hematopoietic system
decreased NK T cell number ( J:120659 )
• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice




Genotype
MGI:4361564
cx4
Allelic
Composition		 Map3k14aly/Map3k14+
RelbTg(H2-K1/GH1)106Bri/Relb+
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k14aly mutation (3 available); any Map3k14 mutation (41 available)
RelbTg(H2-K1/GH1)106Bri mutation (1 available); any Relb mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:120659 )
• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice and RelbTg(H2-K1/GH1)106Bri heterozygotes
decreased circulating interferon-gamma level ( J:120659 )
• alpha-GalCer-treated mice exhibit a reduction in IFN-gamma serum levels compared to in single heterozygotes
decreased Peyer's patch number ( J:120659 )
• greater than in RelbTg(H2-K1/GH1)106Bri heterozygotes
small Peyer's patches ( J:120659 )
• greater than in RelbTg(H2-K1/GH1)106Bri heterozygotes

homeostasis/metabolism
decreased circulating interferon-gamma level ( J:120659 )
• alpha-GalCer-treated mice exhibit a reduction in IFN-gamma serum levels compared to in single heterozygotes

hematopoietic system
decreased NK T cell number ( J:120659 )
• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice and RelbTg(H2-K1/GH1)106Bri heterozygotes




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory