Phenotypes associated with this allele

• Allele Symbol: Olig2^tm1And
• Allele Name: targeted mutation 1, David J Anderson
• Allele ID: MGI:2179515
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Olig1^tm1And/Olig1^tm1And Olig2^tm1And/Olig2^tm1And	involves: 129 * C57BL/6J	MGI:3810327
cx2	Olig1^tm1And/Olig1^tm1And Olig2^tm1And/Olig2^tm1And Tg(Olig2)#Wdr/?	Not Specified	MGI:5696832

Genotype
MGI:3810327

cx1

• Allelic Composition: Olig1^tm1And/Olig1^tm1And; Olig2^tm1And/Olig2^tm1And
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:76446 )

• though present at E18.5, no live births are observed

nervous system

absent oligodendrocytes ( J:76446 )

• no oligodendrocyte progenitors are detected in the hindbrain and spinal cord

abnormal nervous system development ( J:76446 )

• neuroepithelial cells differentiate into astrocytes instead of oligodendrocytes

decreased oligodendrocyte progenitor number ( J:76446 )

• no oligodendrocyte progenitors are detected in the hindbrain and spinal cord

decreased motor neuron number ( J:76446 )

• at E10.5, most Isl1/2+ Hb9+ motor neurons are lost at all axial levels in the spinal cord

• no projecting axons are observed in the ventral root

• at E13.5, somatic and visceral motor neurons are absent from the spinal cord

• at E16.5, somatic but not visceral motor neurons are absent from the hindbrain

abnormal ventral interneuron 2 morphology ( J:76446 )

• at E10.5 and E13.5, the number of V2 interneurons is increased compared to in wild-type mice and they are expanded ventrally

• however, the numbers and distribution of V1 and V3 interneurons are normal

growth/size/body

decreased fetal size ( J:76446 )

• at E18.5

cellular

decreased oligodendrocyte progenitor number ( J:76446 )

• no oligodendrocyte progenitors are detected in the hindbrain and spinal cord

Genotype
MGI:5696832

cx2

• Allelic Composition: Olig1^tm1And/Olig1^tm1And; Olig2^tm1And/Olig2^tm1And; Tg(Olig2)#Wdr/?
• Genetic Background: Not Specified

nervous system

abnormal oligodendrocyte morphology ( J:210099 )

• oligodendrocyte markers are absent in the spinal cord at E17.5 but present in controls

• oligodendrocyte markers are present at relatively low levels relative to controls at E18.5

• oligodendrocyte markers are present at levels comparable to controls at 3 days of age