Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation
(0 available);
any
Slit1 mutation
(70 available)
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nervous system
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N |
• mice exhibit normal morphology and numbers of interneurons during development
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nervous system
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• at E12.5 commissural axons appear disorganized as they exit the floor plate lacking the typical bundled morphology
• at E12.5 more commissural axons stall and fail to exit the floor plate (78% versus 28% in controls) or recross the floor plate (~20% versus 0% in controls; controls in this study were Slit1tm1.1Matl homozygotes)
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• the lateral funiculus (white matter tract) is significantly thinner in triple homozygous mutants compared to controls
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cellular
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• at E12.5 commissural axons appear disorganized as they exit the floor plate lacking the typical bundled morphology
• at E12.5 more commissural axons stall and fail to exit the floor plate (78% versus 28% in controls) or recross the floor plate (~20% versus 0% in controls; controls in this study were Slit1tm1.1Matl homozygotes)
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nervous system
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• at E12.5 commissural axons occasionally recross the floor plate, this is never seen in controls
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• the ventral commissure (bundle of nerve fibers passing from one side to the other in the spinal cord) appears thicker compared to controls
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• the ventral funiculus (white matter tract) appears reduced in mutants compared to controls
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cellular
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• at E12.5 commissural axons occasionally recross the floor plate, this is never seen in controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation
(0 available);
any
Slit1 mutation
(70 available)
Slit2tm1Matl mutation
(2 available);
any
Slit2 mutation
(88 available)
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nervous system
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• some small bundles diverge from the main tract and extend ventrally, at E18.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation
(0 available);
any
Slit1 mutation
(70 available)
Slit2tm1Matl mutation
(2 available);
any
Slit2 mutation
(88 available)
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nervous system
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• thinner and beginning to divide into bundles at E14.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation
(0 available);
any
Slit1 mutation
(70 available)
Slit2tm1Matl mutation
(2 available);
any
Slit2 mutation
(88 available)
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mortality/aging
nervous system
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N |
• mice exhibit normal numbers of interneurons during development
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• density of LOT (guidepost) cells is slightly decreased rostrally near the ventral part of the olfactory bulb
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• highly defasciculated into small axonal bundles fanned all over the ventral side of the telencephalon although a subset of axons continue on the normal trajectory, at E18.5
• medial axons are more severely affected than lateral axons
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• at E13.5 and E16.5, cell proliferation of ganglionic eminences in the subventricular zone is increased compared to in Slit1tm1.1Matl homozygotes
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• in the subventricular zone/intermediate zone and subplate, mic exhibit an increased in neurite process length is, the number of neurites, and the degree of branching
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo3tm1Matl mutation
(1 available);
any
Robo3 mutation
(71 available)
Slit1tm1.1Matl mutation
(0 available);
any
Slit1 mutation
(70 available)
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nervous system
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• embryos show no midline crossing and look identical to Robo3tm1Matl homozygous littermates
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cellular
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• embryos show no midline crossing and look identical to Robo3tm1Matl homozygous littermates
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nervous system
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• embryos show some midline crossing although the majority still fail to cross indicating a partial rescue of the Robo3tm1Matl homozygous phenotype
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cellular
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• embryos show some midline crossing although the majority still fail to cross indicating a partial rescue of the Robo3tm1Matl homozygous phenotype
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Analysis Tools
