Analysis Tools
mortality/aging
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• on a 129S6/SvEvTac genetic backrgound, homozygous mutant embryos are evident at E8.5, although in lower than expected ratios; no mutant embryos are obtained after E9.5
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Allele Symbol Allele Name Allele ID |
Daxxtm1Led targeted mutation 1, Philip Leder MGI:2179457 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• on a 129S6/SvEvTac genetic backrgound, homozygous mutant embryos are evident at E8.5, although in lower than expected ratios; no mutant embryos are obtained after E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• on a 129S6/SvEvTac genetic backrgound, homozygous mutant embryos are evident at E8.5, although in lower than expected ratios; no mutant embryos are obtained after E9.5
• on a 129S6/SvEvTac x Black Swiss outbred background, homozygous mutant mice are identified at E9.5, but not later
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• E7.5 homozygous mutant embryos display significantly increased levels of apoptosis (TUNEL assay)
• at E8.5, high levels of apoptosis are particularly striking in the allantois as well as in the head and tail regions of the neuroepithelium; apoptosis is also noted in the population of fetal hematopoietic cells
• a similar apoptosis phenotype is observed in homozygous mutant cell lines, established by culturing the inner cell mass of blastocysts derived from matings of heterozygous 129/SvEv mice
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• at E8.5, high levels of apoptosis are particularly striking in the allantois
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• at E8.5, high levels of apoptosis are particularly striking in the head and tail regions of the neuroepithelium
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| N |
• at E8.5, extraembryonic structures such as the yolk sac and amnion are apparent, and some primitive fetal blood formation is noted in homozygous mutant embryos
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• E7.5 homozygous mutant embryos display significantly increased levels of apoptosis (TUNEL assay)
• at E8.5, high levels of apoptosis are particularly striking in the allantois as well as in the head and tail regions of the neuroepithelium; apoptosis is also noted in the population of fetal hematopoietic cells
• a similar apoptosis phenotype is observed in homozygous mutant cell lines, established by culturing the inner cell mass of blastocysts derived from matings of heterozygous 129/SvEv mice
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• at E8.5, high levels of apoptosis are particularly striking in the allantois
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• in E7.5 homozygous mutant embryos, ectoderm-derived cells fail to organize as a uniform layer but, rather, remain as a clump of cells
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• at E7.5, homozygous mutant embryos are significantly smaller than wild-type embryos
• by E8.5 and E9.5, the decreased embryo size is highly pronounced
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• at E7.5, H & E staining revealed that homozygous mutant embryos are highly disorganized compared to wild-type embryos
• by E8.5 and E9.5, the extensive disorganization of homozygous mutant embryos is highly pronounced
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• at E8.5, homozygous mutant embryos lack somite formation and fail to develop specific tissue types or organs
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• at E8.5, the placenta is absent in homozygous mutant embryos
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• at E7.5, homozygous mutant embryos are significantly smaller than wild-type embryos
• by E8.5 and E9.5, the decreased embryo size is highly pronounced
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• at E8.5, high levels of apoptosis are particularly striking in the head and tail regions of the neuroepithelium
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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