All Phenotypes Ikbkb<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ikbkb^{tm1a(EUCOMM)Wtsi}/Ikbkb⁺	B6JTyr;B6N-Ikbkb^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5782112
ht2	Ikbkb^M1Btlr/Ikbkb⁺	C57BL/6J-Ikbkb^M1Btlr	MGI:5691988
ht3	Ikbkb^em1Macc/Ikbkb⁺	involves: C57BL/6NCrl	MGI:6444681

Allelic Composition	Ikbkb^{tm1a(EUCOMM)Wtsi}/Ikbkb⁺
Genetic Background	B6JTyr;B6N-Ikbkb^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0028_5_E07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Ikbkb mutation (56 available)

Data Sources

IMPC Data for Ikbkb

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:165965 )

IMPC - WTSI

increased body weight ( J:165965 )

IMPC - WTSI

Allelic Composition	Ikbkb^M1Btlr/Ikbkb⁺
Genetic Background	C57BL/6J-Ikbkb^M1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^M1Btlr mutation (0 available); any Ikbkb mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225271 )

• mice exhibit an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of peripheral CD8+ T cells in CD3 T cells after MCMV infection

abnormal B cell physiology ( J:225271 )

• some mice exhibit a reduced frequency of B1a cells in B1 cells and an increased frequency of B1b cells in B1 cells in the peripheral blood after MCMV infection

abnormal response to infection ( J:225271 )

• after MCMV infection, mice exhibit an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of peripheral CD8+ T cells in CD3 T cells and some mice exhibit a reduced frequency of B1a cells in B1 cells and an increased frequency of B1b cells in B1 cells in the peripheral blood

increased response to antigen ( J:225271 )

• mice exhibit impaired IgE and IgG1 responses to the cysteine protease papain

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225271 )

• mice exhibit an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of peripheral CD8+ T cells in CD3 T cells after MCMV infection

abnormal B cell physiology ( J:225271 )

• some mice exhibit a reduced frequency of B1a cells in B1 cells and an increased frequency of B1b cells in B1 cells in the peripheral blood after MCMV infection

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:290616 )

decreased memory B cell number ( J:290616 )

abnormal effector T cell number ( J:290616 )

• increase in the number of effector T cells

increased regulatory T cell number ( J:290616 )

• small increase in circulating T reg cells and within the thymus

decreased T cell number ( J:290616 )

• T cells are reduced as a proportion of splenocytes

• reduction in absolute number of T cells within spleens

decreased CD4-positive, alpha-beta T cell number ( J:290616 )

• reduction in absolute numbers of CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:290616 )

• reduction in absolute numbers of CD8+ T cells

abnormal T cell activation ( J:290616 )

• increase in T cell activation