Phenotypes associated with this allele

• Allele Symbol: Ptgfr^tm1Sna
• Allele Name: targeted mutation 1, Shuh Narumiya
• Allele ID: MGI:2179271
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgfr^tm1Sna/Ptgfr^tm1Sna	B6.129P2-Ptgfr^tm1Sna	MGI:5517585
hm2	Ptgfr^tm1Sna/Ptgfr^tm1Sna	involves: 129P2/OlaHsd * C57BL/6	MGI:3056551

Genotype
MGI:5517585

hm1

• Allelic Composition: Ptgfr^tm1Sna/Ptgfr^tm1Sna
• Genetic Background: B6.129P2-Ptgfr^tm1Sna

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:197334 )

N • in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal dye extravasation (a measure of edema)

Genotype
MGI:3056551

hm2

• Allelic Composition: Ptgfr^tm1Sna/Ptgfr^tm1Sna
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

endocrine/exocrine glands

abnormal ovary secretion ( J:42113 )

♀ • production of progesterone continues past day 21

♀ • ovariectomy results in parturition

reproductive system

reproductive system phenotype ( J:42113 )

N • females have normal oestrus cycles, become pregnant, and have normal pregnancies

abnormal reproductive system physiology ( J:42113 )

abnormal ovary secretion ( J:42113 )

♀ • production of progesterone continues past day 21

♀ • ovariectomy results in parturition

parturition failure ( J:42113 , J:83575 )

♀ • parturition fails (J:42113)

♀ • all fetuses die in utero by day 23 (J:83575)