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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Erbb2tm1Mul
targeted mutation 1, William Muller
MGI:2179176
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Erbb2tm1Mul/Erbb2tm1Mul involves: 129S1/Sv * 129X1/SvJ * BALB/c MGI:3621733


Genotype
MGI:3621733
hm1
Allelic
Composition		 Erbb2tm1Mul/Erbb2tm1Mul
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Mul mutation (0 available); any Erbb2 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
absent trabeculae carneae ( J:74283 )
• E10.5 embryos lack development of ventricular trabeculae
enlarged heart ( J:74283 )
• seen at E10.5
abnormal blood circulation ( J:74283 )
• reduction in embryonic blood flow
irregular heartbeat ( J:74283 )
• exhibit an irregular heart beat at E10.5

nervous system
abnormal paravertebral ganglion morphology ( J:74283 )
• E10-10.5 embryos lack sympathetic chain ganglia

muscle
absent trabeculae carneae ( J:74283 )
• E10.5 embryos lack development of ventricular trabeculae

growth/size/body
enlarged heart ( J:74283 )
• seen at E10.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory