All Phenotypes Ripk1<tm1Led> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ripk1^tm1Led/Ripk1^tm1Led	involves: 129S6/SvEvTac	MGI:3038877
cx2	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led Xiap^tm1Vdr/Xiap^tm1Vdr	involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6	MGI:5319382
cx3	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺ Xiap^tm1Vdr/Xiap^tm1Vdr	involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6	MGI:5319383
cx4	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL	MGI:5319380
cx5	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL	MGI:5319385

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

lymph node necrosis ( J:46522 )

mortality/aging

postnatal lethality, complete penetrance ( J:46522 )

• no homozygotes survived beyond 3 days after birth

adipose tissue

abnormal brown adipose tissue morphology ( J:46522 )

• tissue damage and granulocyte infiltration

growth/size/body

decreased body weight ( J:46522 )

• 2-3 days after birth homozygotes weighed 1/3 to 1/2 normal

hematopoietic system

abnormal thymus morphology ( J:46522 )

• numerous apoptotic bodies found throughout the thymus

decreased thymocyte number ( J:46522 )

• reduced thymocyte viability at E18

abnormal leukocyte cell number ( J:46522 )

• while WBC counts are normal, there is an increased percentage of myeloid cells and a decrease in peripheral blood lymphocytes

increased spleen red pulp amount ( J:46522 )

homeostasis/metabolism

edema ( J:46522 )

• edema is seen in the neck, axillary, and inguinal areas

immune system

abnormal leukocyte cell number ( J:46522 )

• while WBC counts are normal, there is an increased percentage of myeloid cells and a decrease in peripheral blood lymphocytes

abnormal immune system organ morphology ( J:46522 )

abnormal thymus morphology ( J:46522 )

• numerous apoptotic bodies found throughout the thymus

decreased thymocyte number ( J:46522 )

• reduced thymocyte viability at E18

increased spleen red pulp amount ( J:46522 )

abnormal lymph node morphology ( J:46522 )

• lacked normal architecture and were edematous, necrotic and infiltrated with granulocytes

lymph node necrosis ( J:46522 )

lymph node inflammation ( J:46522 )

integument

abnormal dermal layer morphology ( J:46522 )

• tissue damage and granulocyte infiltration

endocrine/exocrine glands

abnormal thymus morphology ( J:46522 )

• numerous apoptotic bodies found throughout the thymus

decreased thymocyte number ( J:46522 )

• reduced thymocyte viability at E18

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led Xiap^tm1Vdr/Xiap^tm1Vdr
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Ripk1^tm1Led mutation (0 available); any Ripk1 mutation (31 available)
Xiap^tm1Vdr mutation (0 available); any Xiap mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:182515 )

• mice die by E15.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺ Xiap^tm1Vdr/Xiap^tm1Vdr
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:182515 )

• most mice die within 10 weeks of birth

• however, two mice survive for 6 weeks

growth/size/body

decreased body size ( J:182515 )

• two surviving mice

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (31 available)
Ripk1^tm1Led mutation (0 available); any Ripk1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• mice survive to E12.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:182515 )

• mice survive to E15.5

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