All Phenotypes Oprm1<tm1Jep> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Oprm1^tm1Jep
targeted mutation 1, John E Pintar
MGI:2179052

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Jep/Oprm1^tm1Jep	B6.129S-Oprm1^tm1Jep	MGI:4358701
hm2	Oprm1^tm1Jep/Oprm1^tm1Jep	involves: 129S/SvEv	MGI:4358621
ht3	Oprm1^tm1Jep/Oprm1⁺	B6.129S-Oprm1^tm1Jep	MGI:4358702
ht4	Oprm1^tm1Jep/Oprm1⁺	involves: 129S/SvEv	MGI:4358622
cx5	Oprd1^tm1Jep/Oprd1^tm1Jep Oprm1^tm1Jep/Oprm1^tm1Jep Oprm1^tm1Jep/Oprm1^tm1Jep	involves: 129S/SvEv * 129S2/SvPas	MGI:4358720
cx6	Arrb2^tm1Rjl/Arrb2^tm1Rjl Oprm1^tm1Jep/Oprm1^tm1Jep Tg(Th-Oprm1)4Jtw/0	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4355146
cx7	Oprm1^tm1Jep/Oprm1^tm1Jep Tg(Th-Oprm1)4Jtw/0	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:4355145

Allelic Composition	Oprm1^tm1Jep/Oprm1^tm1Jep
Genetic Background	B6.129S-Oprm1^tm1Jep

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:101294 )

• following treatment with amphetamine, mice exhibit a greater increase in locomotor activity compared with similarly treated wild-type mice

abnormal operant conditioning behavior ( J:101294 )

• 2.5 hours before food access, mice exhibit a reduced increased in running wheel activity prior to food access (food anticipitory behavior) compared with similarly treated wild-type mice

• during the 3 hours feeding period, mice exhibit a lower decrease in running wheel activity compared with similarly treated wild-type mice

induced hyperactivity ( J:101294 )

• following treatment with amphetamine, mice exhibit a greater increase in locomotor activity compared with similarly treated wild-type mice

nervous system

impaired ability to fire action potentials ( J:101066 )

• midbrain dopamine neurons exhibit lower firing rates and non-bursting activity compared to in wild-type mice with fewer neurons exhibiting fast firing rates

• unlike in wild-type mice, one third of neurons display no bursting at all

• however, the quality of bursting size, burst duration, and frequency of pikes within bursts are normal

adipose tissue

increased total body fat amount ( J:147786 )

• fat tissue is increased 73% compared to in wild-type mice

increased percent body fat/body weight ( J:147786 )

• mice exhibit a 5% increased in fat as a percentage of body composition compared with wild-type mice

homeostasis/metabolism

increased insulin secretion ( J:147786 )

• mice exhibit a 50% increase in pancreas insulin content compared with wild-type mice

• glucose- and tolbutamide-mediated insulin secretion is increased compared to in wild-type islets

increased circulating insulin level ( J:147786 )

• after glucose challenge

improved glucose tolerance ( J:147786 )

• mice exhibit improved glucose tolerance that does not decrease with age

growth/size/body

increased pancreas weight ( J:147786 )

abnormal lean body mass ( J:147786 )

• while mice exhibit a 11% increase in lean tissue this results is a 5% decrease in lean tissue as a percent of whole body composition compared with wild-type mice

increased body weight ( J:147786 )

• mice exhibit increased body weight compared with wild-type mice except at birth and during the weaning period (2 to 4 weeks)

endocrine/exocrine glands

enlarged pancreatic islets ( J:147786 )

increased pancreas weight ( J:147786 )

increased insulin secretion ( J:147786 )

• mice exhibit a 50% increase in pancreas insulin content compared with wild-type mice

• glucose- and tolbutamide-mediated insulin secretion is increased compared to in wild-type islets

Allelic Composition	Oprm1^tm1Jep/Oprm1^tm1Jep
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:52952 , J:65217 )

• in a tail flick assay, mice treated with morphine, methadone, or DAMGO display nearly no analgesic response unlike in similarly treated wild-type mice (J:52952)

• however, analgesic response to U50,488H, naloxone benzoylhydrazone (NalBzoH), morphine-6beta-glucuronide (M6G), heroine, 6-acetyl-morphine, and D-Penicillamine(2,5)-enkephalin (DPDPE) is normal (J:52952)

• morphine analgesic response is abolished unlike in wild-type mice (J:65217)

enhanced behavioral response to anesthetic ( J:65217 )

• improgan analgesic response is enhanced in female mice compared to in wild-type mice

• however, improgan analgesia in males is normal

impaired behavioral response to anesthetic ( J:52952 , J:65217 )

• in a tail flick assay, mice treated with morphine, methadone, or DAMGO display nearly no analgesic response unlike in similarly treated wild-type mice (J:52952)

• morphine analgesic response is abolished unlike in wild-type mice (J:65217)

Allelic Composition	Oprm1^tm1Jep/Oprm1⁺
Genetic Background	B6.129S-Oprm1^tm1Jep

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:101294 )

• following treatment with amphetamine, mice exhibit a greater increase in locomotor activity compared with similarly treated wild-type mice

abnormal operant conditioning behavior ( J:101294 )

• during the 3 hours feeding period, mice exhibit a lower decrease running wheel activity compared with similarly treated wild-type mice

induced hyperactivity ( J:101294 )

• following treatment with amphetamine, mice exhibit a greater increase in locomotor activity compared with similarly treated wild-type mice

Allelic Composition	Oprm1^tm1Jep/Oprm1⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:52952 , J:65217 )

• in a tail flick assay, mice exhibit an intermediate analgesic response following morphine, methadone, or DAMGO treatment compared with wild-type and homozygous mice (J:52952)

• morphine analgesic response is attenuated compared to in wild-type mice (J:65217)

enhanced behavioral response to anesthetic ( J:65217 )

• improgan analgesic response is enhanced in female mice compared to in wild-type mice

• however, improgan analgesia in males is normal

impaired behavioral response to anesthetic ( J:52952 , J:65217 )

• in a tail flick assay, mice exhibit an intermediate analgesic response following morphine, methadone, or DAMGO treatment compared with wild-type and homozygous mice (J:52952)

• morphine analgesic response is attenuated compared to in wild-type mice (J:65217)

Allelic Composition	Oprd1^tm1Jep/Oprd1^tm1Jep Oprm1^tm1Jep/Oprm1^tm1Jep Oprm1^tm1Jep/Oprm1^tm1Jep
Genetic Background	involves: 129S/SvEv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprd1^tm1Jep mutation (0 available); any Oprd1 mutation (29 available)
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:124042 )

N	• mice exhibit normal nociception prior to opioid infusion

impaired behavioral response to morphine ( J:124042 )

• unlike in wild-type mice, mice exhibit decreased tail-withdrawal latencies demonstrating the abolishment of opioid analgesic responses to acute doses of morphine and oxymorphone

• infusion of morphine results in a decrease in tail withdrawal latency relative to baseline after 2 days unlike similarly treated wild-type mice that display an increase on the first two days and a decrease on days 4 through 7

• infusion of oxymorphone results in reduced tail withdrawal latency compared to baseline at 4 days unlike in similarly treated wild-type mice that exhibit an increase in latency within the first 4 days and a decrease on days 8 through 10

• NMDA receptor blockage with MK-801 does not reverse opioid hyperalgesia unlike in similarly treated wild-type mice

impaired behavioral response to anesthetic ( J:124042 )

• unlike in wild-type mice, mice exhibit decreased tail-withdrawal latencies demonstrating the abolishment of opioid analgesic responses to acute doses of morphine and oxymorphone

• NMDA receptor blockage with MK-801 does not reverse opioid hyperalgesia unlike in similarly treated wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:124042 )

• NMDA receptor blockage with MK-801 does not reverse opioid hyperalgesia unlike in similarly treated wild-type mice

Allelic Composition	Arrb2^tm1Rjl/Arrb2^tm1Rjl Oprm1^tm1Jep/Oprm1^tm1Jep Tg(Th-Oprm1)4Jtw/0
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arrb2^tm1Rjl mutation (2 available); any Arrb2 mutation (27 available)
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (53 available)
Tg(Th-Oprm1)4Jtw mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:151536 )

N	• desensitization and internalization of opioid receptors after met-enkephalin treatment is similar to that in controls

Allelic Composition	Oprm1^tm1Jep/Oprm1^tm1Jep Tg(Th-Oprm1)4Jtw/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (53 available)
Tg(Th-Oprm1)4Jtw mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:151536 )

• maximum hyperpolarization of neurons induced by met-enkephalin (ME) is similar to that seen in wild-type and transgenic wild-type opioid receptor mutant animals; the EC₅₀ for ME is 50% greater than the transgene-only mutants

• desensitization by ME and recovery of desensitization of receptors is similar to wild-type and transgene-only controls

• desensitization and internalization of the mu-opioid receptor (MOR) in response to various MOR agonists is not different in mutants and controls

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