Phenotypes associated with this allele

• Allele Symbol: Asb1^tm1Wehi
• Allele Name: targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
• Allele ID: MGI:2178847
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Asb1^tm1Wehi/Asb1^tm1Wehi	involves: C57BL/6	MGI:2655555

Genotype
MGI:2655555

hm1

• Allelic Composition: Asb1^tm1Wehi/Asb1^tm1Wehi
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:71266 )

N • both male and female homozygotes are fertile

abnormal testis morphology ( J:71266 )

♂ • in 31% of homozygous mutant testes, clusters of tubules completely lack developing spermatocytes

♂ • however, this abnormal testicular morphology has no impact on male fertility

abnormal spermatogenesis ( J:71266 )

♂ • mutant testes frequently show less complete filling of the seminiferous tubules, suggesting reduced spermatogenesis

hematopoietic system

hematopoietic system phenotype ( J:71266 )

N • homozygotes show normal hemopoiesis, both at steady state and in response to several forms of hematopoietic stress

N • also, mutants exhibit no abnormalities of mature blood cells or their progenitors

small spleen ( J:71266 )

• homozygotes show normal splenic architecture but a mild reduction in spleen size

spleen hypoplasia ( J:71266 )

• reduced spleen size reflects a slightly reduced cellularity without loss of any specific cell subset

endocrine/exocrine glands

abnormal testis morphology ( J:71266 )

♂ • in 31% of homozygous mutant testes, clusters of tubules completely lack developing spermatocytes

♂ • however, this abnormal testicular morphology has no impact on male fertility

immune system

small spleen ( J:71266 )

• homozygotes show normal splenic architecture but a mild reduction in spleen size

spleen hypoplasia ( J:71266 )

• reduced spleen size reflects a slightly reduced cellularity without loss of any specific cell subset

integument

thick epidermis ( J:71266 )

• 56% of male homozygotes display thickening of the epithelial layer of skin, either in discrete patches or in a generalized distribution; only 14% of control C57BL/6 male mice exhibit epithelial thickening

• epithelial thickening is associated with squamous differentiation and some keratin formation; however, mutants show no consistent infiltration of cells in the underlying dermis