Phenotypes associated with this allele

• Allele Symbol: Arnt2^tm1Yfk
• Allele Name: targeted mutation 1, Yoshiaki Fujii-Kuriyama
• Allele ID: MGI:2178831
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arnt2^tm1Yfk/Arnt2^tm1Yfk	involves: 129P2/OlaHsd * C57BL/6	MGI:3845882

Genotype
MGI:3845882

hm1

• Allelic Composition: Arnt2^tm1Yfk/Arnt2^tm1Yfk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:74118 )

• no homozygotes survive to 2 weeks after birth

• homozygotes within 1 day of birth are grossly normal

nervous system

abnormal neurohypophysis morphology ( J:74118 )

• arginine vasopressin and oxytocin absent in the posterior lobe

• corticotropin releasing hormone and somatostatin absent in the posterior lobe

abnormal pituitary secretion ( J:74118 )

• arginine vasopressin and oxytocin absent in the posterior lobe

• corticotropin releasing hormone and somatostatin absent in the posterior lobe

enlarged third ventricle ( J:74118 )

• diameter of third ventricle is increased

abnormal paraventricular hypothalamic nucleus morphology ( J:74118 )

• hypocellular in newborn mice

abnormal supraoptic nucleus morphology ( J:74118 )

• hypocellular in newborn mice

endocrine/exocrine glands

abnormal neurohypophysis morphology ( J:74118 )

• arginine vasopressin and oxytocin absent in the posterior lobe

• corticotropin releasing hormone and somatostatin absent in the posterior lobe

abnormal pituitary secretion ( J:74118 )

• arginine vasopressin and oxytocin absent in the posterior lobe

• corticotropin releasing hormone and somatostatin absent in the posterior lobe

homeostasis/metabolism

abnormal pituitary hormone level ( J:74118 )

• arginine vasopressin and oxytocin absent in the posterior lobe

• corticotropin releasing hormone and somatostatin absent in the posterior lobe