Phenotypes associated with this allele

• Allele Symbol: Cebpe^tm1Kgx
• Allele Name: targeted mutation 1, Kleanthis G Xanthopoulos
• Allele ID: MGI:2178607
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cebpe^tm1Kgx/Cebpe^tm1Kgx	involves: 129S6/SvEvTac	MGI:2662526
hm2	Cebpe^tm1Kgx/Cebpe^tm1Kgx	involves: 129S6/SvEvTac * NIH Black Swiss	MGI:2662525

Genotype
MGI:2662526

hm1

• Allelic Composition: Cebpe^tm1Kgx/Cebpe^tm1Kgx
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cebpe^tm1Kgx/Cebpe^tm1Kgx mice exhibit a variety of lesions associated with opportunistic bacetrial infections

mortality/aging

premature death ( J:76024 )

• Background Sensitivity: animals become moribund and die by 2 months of age, earlier than on mixed 129S6/SvEvTac and NIH Black Swiss background

digestive/alimentary system

colitis ( J:76024 )

• many mutants exhibit enterocolitis, associated peritonitis, and abdominal and renal abscesses because of infection with Pseudomonas aeruginosa

peritoneal inflammation ( J:76024 )

• many mutants exhibit peritonitis associated with enterocolitis due to Pseudomonas aeruginosa infection

hematopoietic system

abnormal myelopoiesis ( J:76024 )

abnormal granulocyte differentiation ( J:76024 )

• granulopoiesis is abnormal with a block in maturation of granulocytic lineages

• however, erythropoiesis and lymphopoiesis are normal

abnormal eosinophil differentiation ( J:76024 )

• impaired eosinophil development

abnormal neutrophil differentiation ( J:76024 )

• neutrophil differentiation is impaired in colony-forming unit granulocyte/macrophage colonies; colonies contain mostly promyelocytes and myelocytes and only few metamyelocytes

impaired myelopoiesis ( J:76024 )

• myeloid cell differentiation progresses only to the level of hyposegmented neutrophils

extramedullary hematopoiesis ( J:76024 )

• splenic and hepatic extramedullary hematopoiesis, which is predominantly myeloid

abnormal bone marrow cell morphology/development ( J:76024 )

• myelodysplasia

abnormal common myeloid progenitor cell morphology ( J:76024 )

• increase in granulocytic progenitors in bone marrow

increased bone marrow cell number ( J:76024 )

• bone marrow hyperplasia with proliferation predominantly of myeloid precursor cells

decreased granulocyte number ( J:76024 )

• decrease in Gr-1-positive mature granulocyte population in bone marrow and spleen at 3-4 months of age

decreased eosinophil cell number ( J:76024 )

• decrease in numbers of eosinophils in peripheral blood and bone marrow

abnormal neutrophil morphology ( J:76024 )

• increase in numbers of hyposegmented atypical neutrophils in peripheral blood

increased plasma cell number ( J:76024 )

• reactive regional lymphadenopathy, with plasma cell hyperplasia

abnormal neutrophil physiology ( J:76024 )

• metamyelocytes, and reduced numbers of band neutrophils are seen in mutant peritoneal fluid and peripheral blood, compared with 85% segmented neutrophils in wild-type, indicating impaired neutrophil function

immune system

abnormal myelopoiesis ( J:76024 )

abnormal granulocyte differentiation ( J:76024 )

• granulopoiesis is abnormal with a block in maturation of granulocytic lineages

• however, erythropoiesis and lymphopoiesis are normal

abnormal eosinophil differentiation ( J:76024 )

• impaired eosinophil development

abnormal neutrophil differentiation ( J:76024 )

• neutrophil differentiation is impaired in colony-forming unit granulocyte/macrophage colonies; colonies contain mostly promyelocytes and myelocytes and only few metamyelocytes

impaired myelopoiesis ( J:76024 )

• myeloid cell differentiation progresses only to the level of hyposegmented neutrophils

decreased granulocyte number ( J:76024 )

• decrease in Gr-1-positive mature granulocyte population in bone marrow and spleen at 3-4 months of age

decreased eosinophil cell number ( J:76024 )

• decrease in numbers of eosinophils in peripheral blood and bone marrow

abnormal neutrophil morphology ( J:76024 )

• increase in numbers of hyposegmented atypical neutrophils in peripheral blood

increased plasma cell number ( J:76024 )

• reactive regional lymphadenopathy, with plasma cell hyperplasia

abnormal neutrophil physiology ( J:76024 )

• metamyelocytes, and reduced numbers of band neutrophils are seen in mutant peritoneal fluid and peripheral blood, compared with 85% segmented neutrophils in wild-type, indicating impaired neutrophil function

enlarged lymph nodes ( J:76024 )

• reactive regional lymphadenopathy, with plasma cell hyperplasia

increased inflammatory response ( J:76024 )

• inflammatory infiltrates are characterized by large numbers of atypical hyposegmented granulocytes, mixed with variable numbers of macrophages and lymphocytes

colitis ( J:76024 )

• many mutants exhibit enterocolitis, associated peritonitis, and abdominal and renal abscesses because of infection with Pseudomonas aeruginosa

peritoneal inflammation ( J:76024 )

• many mutants exhibit peritonitis associated with enterocolitis due to Pseudomonas aeruginosa infection

conjunctivitis ( J:76024 )

• many mice develop conjunctivitis due to Pasteurella pneumotropica infection; lesions characterized by cellular infiltrate of atypical granulocytes

osteomyelitis ( J:76024 )

• seen is some mice involving the maxilla and distal hindlimbs

lung inflammation ( J:76024 )

• some mice develop pulmonary abscesses and pneumonia due to Pseudomonas aeruginosa infection

rhinitis ( J:76024 )

• many mice develop rhinitis due to Pasteurella pneumotropica infection; lesions characterized by cellular infiltrate of atypical granulocytes

pleuritis ( J:76024 )

• some mice develop pleuritis due to Pseudomonas aeruginosa infection

increased susceptibility to bacterial infection ( J:76024 )

• increased susceptibility to opportunistic infections

respiratory system

lung inflammation ( J:76024 )

• some mice develop pulmonary abscesses and pneumonia due to Pseudomonas aeruginosa infection

rhinitis ( J:76024 )

• many mice develop rhinitis due to Pasteurella pneumotropica infection; lesions characterized by cellular infiltrate of atypical granulocytes

pleuritis ( J:76024 )

• some mice develop pleuritis due to Pseudomonas aeruginosa infection

skeleton

osteomyelitis ( J:76024 )

• seen is some mice involving the maxilla and distal hindlimbs

abnormal bone marrow morphology ( J:76024 )

• bone marrow exhibits variable numbers of distorted macrophages with intracytoplasmic eosinophilic acicular crystals

vision/eye

conjunctivitis ( J:76024 )

• many mice develop conjunctivitis due to Pasteurella pneumotropica infection; lesions characterized by cellular infiltrate of atypical granulocytes

integument

abnormal skin morphology ( J:76024 )

• subcutaneous abscesses, and superficial and deep cellulitis in some mice

cellular

abnormal granulocyte differentiation ( J:76024 )

• granulopoiesis is abnormal with a block in maturation of granulocytic lineages

• however, erythropoiesis and lymphopoiesis are normal

abnormal eosinophil differentiation ( J:76024 )

• impaired eosinophil development

abnormal neutrophil differentiation ( J:76024 )

• neutrophil differentiation is impaired in colony-forming unit granulocyte/macrophage colonies; colonies contain mostly promyelocytes and myelocytes and only few metamyelocytes

Genotype
MGI:2662525

hm2

• Allelic Composition: Cebpe^tm1Kgx/Cebpe^tm1Kgx
• Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Cebpe^tm1Kgx/Cebpe^tm1Kgx mice exhibit a variety of lesions associated with opportunistic bacetrial infections

mortality/aging

premature death ( J:76024 )

• Background Sensitivity: animals become moribund and die by 5 months of age, later than on a 129S6/SvEvTac background

hematopoietic system

abnormal myelopoiesis ( J:76024 )

abnormal granulocyte differentiation ( J:76024 )

• granulopoiesis is abnormal with a block in maturation of granulocytic lineages

• however, erythropoiesis and lymphopoiesis are normal

abnormal eosinophil differentiation ( J:76024 )

• impaired eosinophil development

abnormal neutrophil differentiation ( J:76024 )

• neutrophil differentiation is impaired in colony-forming unit granulocyte/macrophage colonies; colonies contain mostly promyelocytes and myelocytes and only few metamyelocytes

impaired myelopoiesis ( J:76024 )

• myeloid cell differentiation progresses only to the level of hyposegmented neutrophils

extramedullary hematopoiesis ( J:76024 )

• splenic and hepatic extramedullary hematopoiesis, which is predominantly myeloid

abnormal bone marrow cell morphology/development ( J:76024 )

• myelodysplasia

abnormal common myeloid progenitor cell morphology ( J:76024 )

• increase in granulocytic progenitors in bone marrow

increased bone marrow cell number ( J:76024 )

• bone marrow hyperplasia with proliferation predominantly of myeloid precursor cells

decreased granulocyte number ( J:76024 )

• decrease in Gr-1-positive mature granulocyte population in bone marrow and spleen at 3-4 months of age

decreased eosinophil cell number ( J:76024 )

• decrease in numbers of eosinophils in peripheral blood and bone marrow

abnormal neutrophil morphology ( J:76024 )

• increase in numbers of hyposegmented atypical neutrophils in peripheral blood

increased plasma cell number ( J:76024 )

• reactive regional lymphadenopathy, with plasma cell hyperplasia

abnormal neutrophil physiology ( J:76024 )

• metamyelocytes, and reduced numbers of band neutrophils are seen in mutant peritoneal fluid and peripheral blood, compared with 85% segmented neutrophils in wild-type, indicating impaired neutrophil function

immune system

abnormal myelopoiesis ( J:76024 )

abnormal granulocyte differentiation ( J:76024 )

• granulopoiesis is abnormal with a block in maturation of granulocytic lineages

• however, erythropoiesis and lymphopoiesis are normal

abnormal eosinophil differentiation ( J:76024 )

• impaired eosinophil development

abnormal neutrophil differentiation ( J:76024 )

• neutrophil differentiation is impaired in colony-forming unit granulocyte/macrophage colonies; colonies contain mostly promyelocytes and myelocytes and only few metamyelocytes

impaired myelopoiesis ( J:76024 )

• myeloid cell differentiation progresses only to the level of hyposegmented neutrophils

decreased granulocyte number ( J:76024 )

• decrease in Gr-1-positive mature granulocyte population in bone marrow and spleen at 3-4 months of age

decreased eosinophil cell number ( J:76024 )

• decrease in numbers of eosinophils in peripheral blood and bone marrow

abnormal neutrophil morphology ( J:76024 )

• increase in numbers of hyposegmented atypical neutrophils in peripheral blood

increased plasma cell number ( J:76024 )

• reactive regional lymphadenopathy, with plasma cell hyperplasia

abnormal neutrophil physiology ( J:76024 )

• metamyelocytes, and reduced numbers of band neutrophils are seen in mutant peritoneal fluid and peripheral blood, compared with 85% segmented neutrophils in wild-type, indicating impaired neutrophil function

enlarged lymph nodes ( J:76024 )

• reactive regional lymphadenopathy, with plasma cell hyperplasia

increased inflammatory response ( J:76024 )

• inflammatory infiltrates are characterized by large numbers of atypical hyposegmented granulocytes, mixed with variable numbers of macrophages and lymphocytes

colitis ( J:76024 )

• many mutants exhibit enterocolitis, associated peritonitis, and abdominal and renal abscesses because of infection with Pseudomonas aeruginosa

peritoneal inflammation ( J:76024 )

• many mutants exhibit peritonitis associated with enterocolitis due to Pseudomonas aeruginosa infection

conjunctivitis ( J:76024 )

• many mice develop conjunctivitis and rhinitis due to Pasteurella pneumotropica infection; lesions characterized by cellular infiltrate of atypical granulocytes

osteomyelitis ( J:76024 )

• seen is some mice involving the maxilla and distal hindlimbs

lung inflammation ( J:76024 )

• some mice develop pulmonary abscesses, pneumonia, pleuritis, and due to Pseudomonas aeruginosa infection

rhinitis ( J:76024 )

• many mice develop conjunctivitis and rhinitis due to Pasteurella pneumotropica infection; lesions characterized by cellular infiltrate of atypical granulocytes

increased susceptibility to bacterial infection ( J:76024 )

• increased susceptibility to opportunistic infections

respiratory system

lung inflammation ( J:76024 )

• some mice develop pulmonary abscesses, pneumonia, pleuritis, and due to Pseudomonas aeruginosa infection

rhinitis ( J:76024 )

• many mice develop conjunctivitis and rhinitis due to Pasteurella pneumotropica infection; lesions characterized by cellular infiltrate of atypical granulocytes

skeleton

osteomyelitis ( J:76024 )

• seen is some mice involving the maxilla and distal hindlimbs

abnormal bone marrow morphology ( J:76024 )

• bone marrow exhibits variable numbers of distorted macrophages with intracytoplasmic eosinophilic acicular crystals

vision/eye

conjunctivitis ( J:76024 )

• many mice develop conjunctivitis and rhinitis due to Pasteurella pneumotropica infection; lesions characterized by cellular infiltrate of atypical granulocytes

digestive/alimentary system

colitis ( J:76024 )

• many mutants exhibit enterocolitis, associated peritonitis, and abdominal and renal abscesses because of infection with Pseudomonas aeruginosa

peritoneal inflammation ( J:76024 )

• many mutants exhibit peritonitis associated with enterocolitis due to Pseudomonas aeruginosa infection

integument

abnormal skin morphology ( J:76024 )

• subcutaneous abscesses, and superficial and deep cellulitis in some mice

cellular

abnormal granulocyte differentiation ( J:76024 )

• granulopoiesis is abnormal with a block in maturation of granulocytic lineages

• however, erythropoiesis and lymphopoiesis are normal

abnormal eosinophil differentiation ( J:76024 )

• impaired eosinophil development

abnormal neutrophil differentiation ( J:76024 )

• neutrophil differentiation is impaired in colony-forming unit granulocyte/macrophage colonies; colonies contain mostly promyelocytes and myelocytes and only few metamyelocytes