Analysis Tools
mortality/aging
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• mice receiving a mutant allele from both the mother and father die late in development
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Allele Symbol Allele Name Allele ID |
Minute minute imprinted gene in the Igf2 region MGI:2178160 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice receiving a mutant allele from both the mother and father die late in development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die between E15 and E17
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most postnatal lethality of mice with a paternal allele occurres around P4
• Background Sensitivity: survival is enhanced in M. m. castaneus cross
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• abnormal imprinting of Igf2 occurs with mice receiving the maternal allele having increased growth rates in utero while mice receiving the paternal allele having decreased in utero growth rates
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• severe growth retardation is seen at E13 through birth in mice inheriting a paternal allele
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• placental weight ratios are more severely reduced than fetal weight ratios with mice inheriting a paternal allele
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• mice inheriting a paternal allele exhibit a domed head phenotype
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• mice inheriting a paternal allele exhibit a domed head phenotype
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• severe growth retardation is seen at E13 through birth in mice inheriting a paternal allele
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• at birth, size of mice inheriting a paternal allele is less than 50% of normal
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• adults with a paternal allele are only about 60% of the weight of wild-type littermates
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• postnatal growth is also reduced in mice inheriting a paternal allele, with weight reaching a minimum at about 4 days of age
• adults with a paternal allele are only about 60% of the weight of wild-type littermates
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• severe growth retardation is seen at E13 through birth in mice inheriting a paternal allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• while the expected number of mice inheriting the paternal allele are present at E18, by P1 only one third of expected mice are present
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• abnormal imprinting of Igf2 occurs with mice receiving the maternal allele having increased growth rates in utero while mice receiving the paternal allele having decreased in utero growth rates
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• at E13 mice carrying a paternally inherited allele are 83% of wild-type in weight
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• at E13 placental weight is 78% of wild-type and reaches 56% of wild-type at E18 in mice carrying a paternally inherited mutant allele
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• with embryos inheriting a maternal allele
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• at birth mice carrying a paternally inherited allele are 55% of wild-type in size
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• at birth, mice carrying a paternally inherited allele are 53% of wild-type weight
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• in mice carrying a paternally inherited allele the size reduction observed at birth is maintained into adulthood
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• mice inheriting maternal allele measure 113% of wild-type and overgrowth reaches 108% of wild-type by P0
• mice inherting maternal allele have increased prenatal growth rates
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• at E13 mice carrying a paternally inherited allele are 83% of wild-type in weight
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: survival is enhanced in M. m. castaneus cross
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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