Phenotypes associated with this allele

• Allele Symbol: Tcf3^tm2Cmu
• Allele Name: targeted mutation 2, Cornelis Murre
• Allele ID: MGI:2178143
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf3^tm2Cmu/Tcf3^tm2Cmu	involves: 129P2/OlaHsd	MGI:3702030

Genotype
MGI:3702030

hm1

• Allelic Composition: Tcf3^tm2Cmu/Tcf3^tm2Cmu
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal lymphopoiesis ( J:118827 )

• percentage of common lymphoid progenitors (CLPs) in bone marrow is reduced 50-95% compared to heterozygous mice

absent pro-B cells ( J:118827 )

• pro-B cells are completely absent in mutants

decreased dendritic cell number ( J:118827 )

• dendritic cell precursors in bone marrow are reduced ~5-fold compared to heterozygotes

absent pre-B cells ( J:118827 )

• pre-B cells are virtually undetectable in mutants

decreased NK cell number ( J:118827 )

• splenic natural killer cells are reduced 3-fold compared to heterozygotes

immune system

abnormal lymphopoiesis ( J:118827 )

• percentage of common lymphoid progenitors (CLPs) in bone marrow is reduced 50-95% compared to heterozygous mice

absent pro-B cells ( J:118827 )

• pro-B cells are completely absent in mutants

decreased dendritic cell number ( J:118827 )

• dendritic cell precursors in bone marrow are reduced ~5-fold compared to heterozygotes

absent pre-B cells ( J:118827 )

• pre-B cells are virtually undetectable in mutants

decreased NK cell number ( J:118827 )

• splenic natural killer cells are reduced 3-fold compared to heterozygotes

cellular

abnormal cell death ( J:118827 )

• frequencies of apoptotic cells are low, but a 2-fold accumulation of dead pre- pro- B cells over controls is observed in mutants

increased cell proliferation ( J:118827 )

• CLPs and pre- pro- B cells from mutants exhibit 2-fold greater proliferation compared to controls