All Phenotypes Tyrp1<isa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tyrp1^isa
iris stromal atrophy
MGI:2178126

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyrp1^isa/Tyrp1^isa	DBA/2J	MGI:2178288
hm2	Tyrp1^isa/Tyrp1^isa	involves: C57BL/6J * DBA/2J	MGI:2178292
cx3	Gpnmb^R150X/Gpnmb^R150X Tyrp1^isa/Tyrp1^isa	DBA/2J	MGI:2178287
cx4	Gpnmb^R150X/Gpnmb^R150X Tyrp1^isa/Tyrp1^isa	involves: C57BL/6J * DBA/2J	MGI:2178293

Allelic Composition	Tyrp1^isa/Tyrp1^isa
Genetic Background	DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^isa mutation (2 available); any Tyrp1 mutation (160 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iris stroma morphology ( J:54013 )

• atrophy

Allelic Composition	Tyrp1^isa/Tyrp1^isa
Genetic Background	involves: C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^isa mutation (2 available); any Tyrp1 mutation (160 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iris stroma morphology ( J:54013 )

• atrophy

Allelic Composition	Gpnmb^R150X/Gpnmb^R150X Tyrp1^isa/Tyrp1^isa
Genetic Background	DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpnmb^R150X mutation (3 available); any Gpnmb mutation (35 available)
Tyrp1^isa mutation (2 available); any Tyrp1 mutation (160 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina ganglion cell degeneration ( J:54013 )

• loss of retinal ganglion cells

optic nerve atrophy ( J:54013 )

abnormal iris pigment epithelium ( J:54013 )

• atrophy

abnormal iris stroma morphology ( J:54013 )

• atrophy

pigmentation

abnormal iris pigment epithelium ( J:54013 )

• atrophy

nervous system

retina ganglion cell degeneration ( J:54013 )

• loss of retinal ganglion cells

optic nerve atrophy ( J:54013 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pigment dispersion syndrome		DOID:0060680	OMIM:600510	J:54013

Allelic Composition	Gpnmb^R150X/Gpnmb^R150X Tyrp1^isa/Tyrp1^isa
Genetic Background	involves: C57BL/6J * DBA/2J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina ganglion cell degeneration ( J:54013 )

• loss of retinal ganglion cells

optic nerve atrophy ( J:54013 )

abnormal iris pigment epithelium ( J:54013 )

• atrophy

abnormal iris stroma morphology ( J:54013 )

• atrophy

pigmentation

abnormal iris pigment epithelium ( J:54013 )

• atrophy

nervous system

retina ganglion cell degeneration ( J:54013 )

• loss of retinal ganglion cells

optic nerve atrophy ( J:54013 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pigment dispersion syndrome		DOID:0060680	OMIM:600510	J:54013

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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