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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf3tm1Cmu
targeted mutation 1, Cornelis Murre
MGI:2178119
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcf3tm1Cmu/Tcf3tm1Cmu either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N) MGI:3776822
ht2
 		Tcf3tm1Cmu/Tcf3+ either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N) MGI:3776820
cx3
 		Id2tm1Yyk/Id2tm1Yyk
Tcf3tm1Cmu/Tcf3+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3776818
cx4
 		Id2tm1Yyk/Id2tm1Yyk
Tcf3tm1Cmu/Tcf3tm1Cmu 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3776819
cx5
 		Pax1un/Pax1+
Tcf3tm1Cmu/Tcf3tm1Cmu 		involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:3776838


Genotype
MGI:3776822
hm1
Allelic
Composition		 Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic
Background		 either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Cmu mutation (0 available); any Tcf3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:67011 )
• mice die between 1 and 4 days after birth of infection or through cannibalization
• only 5% of mice survive past weaning

immune system
abnormal immunoglobulin V(D)J recombination ( J:67011 )
• mice are unable to perform B cell and germ line DJ rearrangement unlike wild-type mice
abnormal immunoglobulin heavy chain V(D)J recombination ( J:67011 )
• mice cannot rearrange IgH DJ segments and VDJ joints are not found in fetal livers as in wild-type and heterozygous mice
abnormal T cell subpopulation ratio ( J:67011 )
• the ratio of CD4 to CD8 T cells in the thymus is altered likely due to infection, stress or both
decreased lymphocyte cell number ( J:67011 )
• lymphoid cell numbers in the thymus and spleen are decreased 3-fold compared to in wild-type mice
decreased B cell number ( J:67011 )
• B220+IgM B cells are absent
• 3% of bone marrow cells are B220+ CD43+ compared to 6% in wild-type mice
• 3% of bone marrow cells are B220+ CD43- compared to 26% in wild-type mice

hematopoietic system
abnormal blood cell morphology/development ( J:67011 )
• peripheral blood contains 3-fold nucleated cells than wild-type blood
abnormal immunoglobulin V(D)J recombination ( J:67011 )
• mice are unable to perform B cell and germ line DJ rearrangement unlike wild-type mice
abnormal immunoglobulin heavy chain V(D)J recombination ( J:67011 )
• mice cannot rearrange IgH DJ segments and VDJ joints are not found in fetal livers as in wild-type and heterozygous mice
abnormal T cell subpopulation ratio ( J:67011 )
• the ratio of CD4 to CD8 T cells in the thymus is altered likely due to infection, stress or both
decreased lymphocyte cell number ( J:67011 )
• lymphoid cell numbers in the thymus and spleen are decreased 3-fold compared to in wild-type mice
decreased B cell number ( J:67011 )
• B220+IgM B cells are absent
• 3% of bone marrow cells are B220+ CD43+ compared to 6% in wild-type mice
• 3% of bone marrow cells are B220+ CD43- compared to 26% in wild-type mice




Genotype
MGI:3776820
ht2
Allelic
Composition		 Tcf3tm1Cmu/Tcf3+
Genetic
Background		 either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Cmu mutation (0 available); any Tcf3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:67011 )
• B220+IgM B cells are reduced to 58% compared to 64% in wild-type mice

hematopoietic system
decreased B cell number ( J:67011 )
• B220+IgM B cells are reduced to 58% compared to 64% in wild-type mice




Genotype
MGI:3776818
cx3
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Tcf3tm1Cmu/Tcf3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (19 available)
Tcf3tm1Cmu mutation (0 available); any Tcf3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:125739 )
• natural killer cell development is partially rescued in bone marrow
absent axillary lymph nodes ( J:125739 )
• absent in most mice
absent brachial lymph nodes ( J:125739 )
• absent in most mice
absent inguinal lymph nodes ( J:125739 )
• absent in most mice

hematopoietic system
decreased NK T cell number ( J:125739 )
• natural killer cell development is partially rescued in bone marrow




Genotype
MGI:3776819
cx4
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (19 available)
Tcf3tm1Cmu mutation (0 available); any Tcf3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:125739 )
N
• production of lymphoid tissue inducing cells are restored
decreased B cell number ( J:125739 )
• mature B cells are absent
decreased NK T cell number ( J:125739 )
• mature natural killer cells in the blood and spleen are reduced compared to in wild-type mice
• however, natural killer cell development is rescued in bone marrow

hematopoietic system
decreased B cell number ( J:125739 )
• mature B cells are absent
decreased NK T cell number ( J:125739 )
• mature natural killer cells in the blood and spleen are reduced compared to in wild-type mice
• however, natural killer cell development is rescued in bone marrow




Genotype
MGI:3776838
cx5
Allelic
Composition		 Pax1un/Pax1+
Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax1un mutation (6 available); any Pax1 mutation (28 available)
Tcf3tm1Cmu mutation (0 available); any Tcf3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:103567 )
• most mice die postnatally due to are cannibalization

reproductive system

nervous system
open neural tube ( J:103567 )
• mice are born with non-lethal neural tube defects at the lumbosacral region over which skin grows

renal/urinary system
abnormal renal/urinary system morphology ( J:103567 )
• mice exhibit high outflow tract resistance

immune system
abnormal T cell differentiation ( J:103567 )
• T cell transition to double positive is partially blocked
abnormal T cell subpopulation ratio ( J:103567 )
• the ratio of CD4 over CD8 T cells is reduced compared to in wild-type mice

limbs/digits/tail

hematopoietic system
abnormal T cell differentiation ( J:103567 )
• T cell transition to double positive is partially blocked
abnormal T cell subpopulation ratio ( J:103567 )
• the ratio of CD4 over CD8 T cells is reduced compared to in wild-type mice

embryo
open neural tube ( J:103567 )
• mice are born with non-lethal neural tube defects at the lumbosacral region over which skin grows

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
neural tube defect DOID:0080074 OMIM:301410
OMIM:601634
 J:103567




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory