Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1.1Dwr mutation
(0 available);
any
F3 mutation
(24 available)
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cardiovascular system
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• mice exhibit enhanced retinal revascularization following oxygen induced retinopathy; the superficial vascular plexus reforms more quickly than in wild-type mice
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vision/eye
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• mice exhibit enhanced retinal revascularization following oxygen induced retinopathy; the superficial vascular plexus reforms more quickly than in wild-type mice
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Allelic
Composition |
F3tm1.1Dwr/F3tm1.1Dwr
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1.1Dwr mutation
(0 available);
any
F3 mutation
(24 available)
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hematopoietic system
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N |
• mice exhibit normal homeostasis and pathological thrombosis
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Allelic
Composition |
F3tm1.1Dwr/F3tm1.1Dwr
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * MF1 * Swiss |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1.1Dwr mutation
(0 available);
any
F3 mutation
(24 available)
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mortality/aging
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• mice challenged with endotoxin exhibit increased survival compared with similarly treated wild-type mice
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immune system
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• reduced after endotoxin challenge
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• reduced after endotoxin challenge
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• leukocyte rolling is reduced after endotoxin challenge while rolling velocity is increased compared to in similarly treated wild-type mice
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• 6 hours after endotoxin challenge, leukocytosis is attenuated compared to in similarly treated wild-type mice
• 1 hour after endotoxin challenge, accumulation of pulmonary leukocytes as measured by MPO activity is decreased compared to in similarly treated wild-type mice
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• 6 and 24 hours after endotoxin challenge
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• 6 hours after endotoxin challenge
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• following endotoxin challenge, mice exhibit a slower increase in IL1b levels compared with similarly treated wild-type mice
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• following endotoxin challenge, mice exhibit a sharper decline in IL6 levels 24 hours after challenge compared with similarly treated wild-type mice
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• following endotoxin challenge, mice exhibit decreased peak serum TNF-alpha levels compared with similarly treated wild-type mice
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• mice challenged with endotoxin exhibit increased survival, and decreased peak serum TNF-alpha levels, a slower rise in IL1b levels, a sharper decline in IL6 levels 24 hours after challenge, attenuated leukocytosis 6 hours after challenge, decreased neutrophil counts 6 and 24 hours after challenge, decreased B cell numbers 6 hours after challenge, decreased MPO activity 1 hour after challenge, decreased polymononuclear infiltration, and reduced leukocyte recruitment parameterd compared with similarly treated wild-type mice
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homeostasis/metabolism
hematopoietic system
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• reduced after endotoxin challenge
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• reduced after endotoxin challenge
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• leukocyte rolling is reduced after endotoxin challenge while rolling velocity is increased compared to in similarly treated wild-type mice
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• 6 hours after endotoxin challenge, leukocytosis is attenuated compared to in similarly treated wild-type mice
• 1 hour after endotoxin challenge, accumulation of pulmonary leukocytes as measured by MPO activity is decreased compared to in similarly treated wild-type mice
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• 6 and 24 hours after endotoxin challenge
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• 6 hours after endotoxin challenge
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cardiovascular system
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• vascular smooth muscle cells (VSMCs) fail to exhibit an increase in FFR-FVIIa-induced migration compared with wild-type cells
• however, migration of VSMCs towards fibronectin and neointimal proliferation of VSMCs after wire injury are normal
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• after artery injury, the number of proliferating VSMCs in media is increased compared to wild-type cells
• VSMCs isolated from the aorta exhibit increased proliferation compared to wild-type cells independent of FFR-FVIIa
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• following transluminal wire injury or ligation of the carotid artery, the intima to media ratio is decreased compared to in similarly treated wild-type mice due to a 54% and 32% increase, respectively, in medial area
• after artery injury, the number of proliferating VSMCs in media is increased compared to wild-type cells
• however, neointimal area is not statistically different
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muscle
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• vascular smooth muscle cells (VSMCs) fail to exhibit an increase in FFR-FVIIa-induced migration compared with wild-type cells
• however, migration of VSMCs towards fibronectin and neointimal proliferation of VSMCs after wire injury are normal
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• after artery injury, the number of proliferating VSMCs in media is increased compared to wild-type cells
• VSMCs isolated from the aorta exhibit increased proliferation compared to wild-type cells independent of FFR-FVIIa
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cellular
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• after artery injury, the number of proliferating VSMCs in media is increased compared to wild-type cells
• VSMCs isolated from the aorta exhibit increased proliferation compared to wild-type cells independent of FFR-FVIIa
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• reduced after endotoxin challenge
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• reduced after endotoxin challenge
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• leukocyte rolling is reduced after endotoxin challenge while rolling velocity is increased compared to in similarly treated wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rtm1Pago mutation
(0 available);
any
F2r mutation
(23 available)
F3tm1.1Dwr mutation
(0 available);
any
F3 mutation
(24 available)
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cardiovascular system
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• mice exhibit enhanced retinal revascularization following oxygen induced retinopathy; the superficial vascular plexus reforms more quickly than in wild-type mice
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vision/eye
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• mice exhibit enhanced retinal revascularization following oxygen induced retinopathy; the superficial vascular plexus reforms more quickly than in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Bpd mutation
(0 available);
any
F2rl1 mutation
(58 available)
F3tm1.1Dwr mutation
(0 available);
any
F3 mutation
(24 available)
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cardiovascular system
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N |
• retinal neoangiogenesis after oxygen induced retinopathy is similar to wild-type mice with mice showing normal regrowth of the retinal vascular network under hypoxia
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Analysis Tools