Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt19tm2Mmt mutation
(0 available);
any
Krt19 mutation
(19 available)
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normal phenotype
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• homozygotes are viable, fertile, and phenotypically indistinguishable from their wild-type and heterozygous control littermates
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt19tm2Mmt mutation
(0 available);
any
Krt19 mutation
(19 available)
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mortality/aging
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• Background Sensitivity: fewer homozygotes than expected are recovered after one or two backcrosses to FBV/N whereas normal numbers of homozygotes are obtained from heterozygous crosses between parents in the C57BL/6 and 129/Sv backgrounds (F1) or after one or two backcrosses to C57BL/6
• however, surviving homozygotes are viable, fertile, and phenotypically indistinguishable from heterozygous and wild-type littermates in terms of gross anatomy, histology, and behavior up to 20 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt19tm2Mmt mutation
(0 available);
any
Krt19 mutation
(19 available)
Krt8tm1Rgo mutation
(1 available);
any
Krt8 mutation
(34 available)
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mortality/aging
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• after E9.5, the number of double homozygotes declines gradually, with increasing numbers of necrotic remnants and resorption sites
• although some double homozygotes are still alive at E9.75-E10.5, they exhibit small placentas and varying degrees of growth retardation
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embryo
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• at E9.75-E10.5, live double homozygotes display varying degrees of growth retardation
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• at E10.5, the allantois is poorly formed and shows signs of degeneration
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• as early as E9.5, double homozygotes display placental defects that cause flooding of the maternal blood into the embryonic placenta
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• at E9.5, labyrinthine trophoblast cells are decreased in number and appear to be poorly organized
• at E10.5, degeneration of the labyrinthine trophoblasts is observed
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• by E10.5, placental vascular structures are deteriorated while maternal and embryonic blood cells display signs of degeneration
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• at E9.75-E10.5, placentas are smaller than normal
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• at E10.5, trophoblastic tissues contain lesions filled with unnucleated maternal erythrocytes as well as some large and nucleated embryonic erythrocytes
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• at E9.5, giant trophoblasts are pulled apart and display significantly larger cell bodies and nuclei
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• a significant increase in the number of secondary giant cells is noted at E9.5
• at E10.5, multiple layers of giant cells are observed
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• at E10.5, degeneration of the spongiotrophoblasts is observed
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• at E9.5, spongiotrophoblast cells appear to be poorly organized
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• at E9.5, spongiotrophoblast cells are decreased in number
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• at E9.5, double homozygotes display flooding of maternal blood into the embryonic placenta in the absence of overt clotting
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growth/size/body
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• at E9.75-E10.5, live double homozygotes display varying degrees of growth retardation
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cardiovascular system
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• by E10.5, placental vascular structures are deteriorated while maternal and embryonic blood cells display signs of degeneration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt18tm1Tmm mutation
(2 available);
any
Krt18 mutation
(28 available)
Krt19tm2Mmt mutation
(0 available);
any
Krt19 mutation
(19 available)
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mortality/aging
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• no homozygotes at birth
• embryonic death between E9.5 and E10.5
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embryo
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• embryos smaller than controls but otherwise normal at E9.5
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• bleeding in extraembryonic tissues between the maternal deciduas and yolk sac at E10.5
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• trophoblast giant cells were cytolytic
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• placentas smaller in diameter but otherwise normally developed
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growth/size/body
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• embryos smaller than controls but otherwise normal at E9.5
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Analysis Tools
