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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ihh+
wild type
MGI:2177548
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ihhtm1.1Dcha/Ihh+ either: (involves: 129S/SvEv * FVB/N) or (involves: 129S/SvEv * FVB/N * ICR) MGI:3842983
ht2
 		Ihhtm1Amc/Ihh+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3584274
cn3
 		Ihhtm1Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB MGI:3584276
cn4
 		Ihhtm2Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N MGI:3584277
cx5
 		Gpc6tm1Lex/Gpc6+
Ihhtm1Amc/Ihh+ 		involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6N MGI:6098736


Genotype
MGI:3842983
ht1
Allelic
Composition		 Ihhtm1.1Dcha/Ihh+
Genetic
Background		 either: (involves: 129S/SvEv * FVB/N) or (involves: 129S/SvEv * FVB/N * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1.1Dcha mutation (0 available); any Ihh mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
brachyphalangia ( J:147878 )
• the middle phalanges on digits II and V are shortened
delayed endochondral bone ossification ( J:147878 )
• expression analysis indicates a delay in endochondral bone ossification at E14.5

limbs/digits/tail
brachyphalangia ( J:147878 )
• the middle phalanges on digits II and V are shortened




Genotype
MGI:3584274
ht2
Allelic
Composition		 Ihhtm1Amc/Ihh+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1Amc mutation (1 available); any Ihh mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased long bone epiphyseal plate size ( J:99641 )
• modest shortening of the growth plate




Genotype
MGI:3584276
cn3
Allelic
Composition		 Ihhtm1Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1Amc mutation (1 available); any Ihh mutation (22 available)
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased long bone epiphyseal plate size ( J:99641 )
• growth plate is expanded, however less than in compound heterozygous mice that contain Ihh




Genotype
MGI:3584277
cn4
Allelic
Composition		 Ihhtm2Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm2Amc mutation (0 available); any Ihh mutation (22 available)
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone hypertrophic chondrocyte zone ( J:99641 )
• elongation of the columnar region
abnormal chondrocyte differentiation ( J:99641 )
• ectopic hypertrophic differentiation in growth plates




Genotype
MGI:6098736
cx5
Allelic
Composition		 Gpc6tm1Lex/Gpc6+
Ihhtm1Amc/Ihh+
Genetic
Background		 involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc6tm1Lex mutation (3 available); any Gpc6 mutation (44 available)
Ihhtm1Amc mutation (1 available); any Ihh mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased fetal weight ( J:245694 )
• unlike single heterozygotes at E17.5

limbs/digits/tail
short femur ( J:245694 )
• unlike single heterozygotes at E17.5

skeleton
short femur ( J:245694 )
• unlike single heterozygotes at E17.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory