All Phenotypes E2f3<tm1Lees> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	E2f3^tm1Lees/E2f3^tm1Lees	involves: 129S2/SvPas	MGI:3840472
hm2	E2f3^tm1Lees/E2f3^tm1Lees	involves: 129S2/SvPas * C57BL/6	MGI:3722935
ht3	E2f3^tm1Lees/E2f3⁺	involves: 129S2/SvPas * C57BL/6	MGI:3722936
cx4	E2f1^tm1Njd/E2f1⁺ E2f3^tm1Lees/E2f3^tm1Lees	involves: 129S2/SvPas	MGI:3840607
cx5	E2f1^tm1Njd/E2f1^tm1Njd E2f3^tm1Lees/E2f3^tm1Lees	involves: 129S2/SvPas	MGI:3840609
cx6	E2f1^tm1Njd/E2f1^tm1Njd E2f3^tm1Lees/E2f3⁺	involves: 129S2/SvPas	MGI:3840610

Allelic Composition	E2f3^tm1Lees/E2f3^tm1Lees
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3^tm1Lees mutation (1 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:75765 )

• increased level of mortality

• only 30% of expected homozygotes present at E18.5

• no viable neonates

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:75765 )

• deaths begin at around 7 months

• average life span is 16.6 months

postnatal lethality, incomplete penetrance ( J:65128 , J:75765 )

• only one quarter of expected mice are present at weaning (J:65128)

• many mice born alive fail to thrive and die by 48 hours (J:75765)

embryonic lethality during organogenesis, incomplete penetrance ( J:75765 )

• 29% of homozygotes are dead by E13.5

cellular

abnormal cell physiology ( J:65128 )

• variation in proliferation and growth rates are observed between different mouse embryonic fibroblast preparations due to the genetic background

abnormal cell cycle ( J:65128 )

• using a [³H]thymidine-incorporation assay after exposure to serum following serum starvation, cell cycle progression in mouse embryonic fibroblast cells (MEFs) is slower than in wild-type MEFs

• using a BrdU-incorporation assay, DNA synthesis in mouse embryonic fibroblast cells (MEFs) is slowed and its rate of occurrence is reduced relative to in wild-type MEFs

decreased cell proliferation ( J:65128 )

• although variation in proliferation rates are observed between different mouse embryonic fibroblast (MEF) preparations due to the genetic background, doubling time of MEFs is twice as long as that of MEFs from wild-type embryos

growth/size/body

slow postnatal weight gain ( J:75765 )

• surviving mice fail to gain weight at the same rate as littermates

decreased fetal weight ( J:75765 )

• significantly decreased weight at E18.5

respiratory system

pulmonary edema ( J:75765 )

pleural effusion ( J:75765 )

• bilateral pleural effusions

lung inflammation ( J:75765 )

• macrophage in alveolar spaces

respiratory distress ( J:75765 )

• dyspnea in the last few days of life

homeostasis/metabolism

abnormal cardiac thrombosis ( J:75765 )

• clot formation specific to the heart

• no pulmonary emboli

• sometimes in the left ventricle

abnormal atrial thrombosis ( J:75765 )

• massive thrombi in the left atria

pulmonary edema ( J:75765 )

pleural effusion ( J:75765 )

• bilateral pleural effusions

cardiovascular system

congestive heart failure ( J:75765 )

• cause of death in about 85% of mice

immune system

lung inflammation ( J:75765 )

• macrophage in alveolar spaces

integument

ruffled hair ( J:75765 )

• in the last month or two of life

Allelic Composition	E2f3^tm1Lees/E2f3⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3^tm1Lees mutation (1 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:65128 )

• some mouse embryonic cells (MEFs) grow as well as wild-type MEFs while others grow at a rate intermediate between wild-type and homozygous nulls

Allelic Composition	E2f1^tm1Njd/E2f1⁺ E2f3^tm1Lees/E2f3^tm1Lees
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1^tm1Njd mutation (1 available); any E2f1 mutation (25 available)
E2f3^tm1Lees mutation (1 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:75765 )

• mice do not survive to E18.5 but are present at E13.5

Allelic Composition	E2f1^tm1Njd/E2f1^tm1Njd E2f3^tm1Lees/E2f3^tm1Lees
Genetic Background	involves: 129S2/SvPas

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:75765 )

• die between E9.5 and E10.5

• embryos normal at E9.5

• much smaller than littermates at E10.5

Allelic Composition	E2f1^tm1Njd/E2f1^tm1Njd E2f3^tm1Lees/E2f3⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

slow postnatal weight gain ( J:75765 )

• surviving mice fail to gain weight at the same rate as littermates

reproductive system

testicular atrophy ( J:75765 )

• exacerbated

• no loss of leydig cells

endocrine/exocrine glands

testicular atrophy ( J:75765 )

• exacerbated

• no loss of leydig cells

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