Phenotypes associated with this allele

• Allele Symbol: E2f3^tm1.2Gle
• Allele Name: targeted mutation 1.2, Gustavo Leone
• Allele ID: MGI:2177428
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	E2f3^tm1.2Gle/E2f3^tm1.2Gle	involves: 129P2/OlaHsd * C57BL/6	MGI:3722932

Genotype
MGI:3722932

hm1

• Allelic Composition: E2f3^tm1.2Gle/E2f3^tm1.2Gle
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:75726 )

• fewer than expected mice are born

• however, mice survive into adulthood and are fertile

cellular

abnormal cell physiology ( J:75726 )

• growth rate of mouse embryonic fibroblasts from E13.5 embryos is reduced

• adenovirus-Myc fails to induce S phase as it does in wild-type mouse embryonic fibroblasts