All Phenotypes E2f3<tm1.1Gle> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

E2f3^tm1.1Gle
targeted mutation 1.1, Gustavo Leone
MGI:2177317

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	E2f3^tm1.1Gle/E2f3^tm1.1Gle	129-E2f3^tm1.1Gle	MGI:3806826
hm2	E2f3^tm1.1Gle/E2f3^tm1.1Gle	B6.129P2-E2f3^tm1.1Gle	MGI:3806825
hm3	E2f3^tm1.1Gle/E2f3^tm1.1Gle	FVB.129P2-E2f3^tm1.1Gle	MGI:3806824
hm4	E2f3^tm1.1Gle/E2f3^tm1.1Gle	involves: 129P2/OlaHsd * C57BL/6J	MGI:3806828
hm5	E2f3^tm1.1Gle/E2f3^tm1.1Gle	involves: 129P2/OlaHsd * C57BL/6J * FVB	MGI:3806829
hm6	E2f3^tm1.1Gle/E2f3^tm1.1Gle	involves: 129P2/OlaHsd * FVB	MGI:3806830
cn7	E2f3^tm1.1Gle/E2f3^tm1.1Gle Rbl1^tm1Htr/Rbl1^tm1Htr Tg(Pax6-cre,GFP)2Pgr/?	involves: 129 * C57BL/6 * FVB/N * NMRI	MGI:3722920
cn8	E2f1^tm1Meg/E2f1^tm1Meg E2f3^tm1.1Gle/E2f3^tm1.1Gle Rbl1^tm1Htr/Rbl1^tm1Htr Tg(Pax6-cre,GFP)2Pgr/?	involves: 129 * C57BL/6 * FVB/N * NMRI	MGI:3722927

Allelic Composition	E2f3^tm1.1Gle/E2f3^tm1.1Gle
Genetic Background	129-E2f3^tm1.1Gle

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3^tm1.1Gle mutation (0 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:138289 )

• Background Sensitivity: unlike mice on a mixed background, mice on a pure 129 background display complete embryonic lethality

Allelic Composition	E2f3^tm1.1Gle/E2f3^tm1.1Gle
Genetic Background	B6.129P2-E2f3^tm1.1Gle

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3^tm1.1Gle mutation (0 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:138289 )

• Background Sensitivity: unlike mice on a mixed background, mice on a congenic C57BL/6J background display complete embryonic lethality

Allelic Composition	E2f3^tm1.1Gle/E2f3^tm1.1Gle
Genetic Background	FVB.129P2-E2f3^tm1.1Gle

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3^tm1.1Gle mutation (0 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:138289 )

• Background Sensitivity: unlike mice on a mixed background, mice on a congenic FVB background display complete embryonic lethality

Allelic Composition	E2f3^tm1.1Gle/E2f3^tm1.1Gle
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3^tm1.1Gle mutation (0 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:138289 )

N	• Background Sensitivity: unlike mice on an inbred background, in mice on a mixed background no significant embryonic lethality is seen

Allelic Composition	E2f3^tm1.1Gle/E2f3^tm1.1Gle
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3^tm1.1Gle mutation (0 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:138289 )

N	• Background Sensitivity: unlike mice on an inbred background, in mice on a mixed background no significant embryonic lethality is seen

Allelic Composition	E2f3^tm1.1Gle/E2f3^tm1.1Gle
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3^tm1.1Gle mutation (0 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:138289 )

N	• Background Sensitivity: unlike mice on an inbred background, in mice on a mixed background no significant embryonic lethality is seen

Allelic Composition	E2f3^tm1.1Gle/E2f3^tm1.1Gle Rbl1^tm1Htr/Rbl1^tm1Htr Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background	involves: 129 * C57BL/6 * FVB/N * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3^tm1.1Gle mutation (0 available); any E2f3 mutation (32 available)
Rbl1^tm1Htr mutation (0 available); any Rbl1 mutation (60 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

decreased retina ganglion cell number ( J:124204 )

• apoptosis eliminates most retinal ganglion cells

decreased retina rod cell number ( J:124204 )

• apoptosis eliminates many rod cells

abnormal amacrine cell morphology ( J:124204 )

• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells

• however, markers of SAC differentiation are restored

• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis

abnormal retina bipolar cell morphology ( J:124204 )

• apoptosis eliminates most bipolar cells

abnormal eye development ( J:124204 )

• retinal transition cells (RTC) undergo ectopic cell divisions

• however, markers of starburst amacrine cell differentiation are restored

nervous system

decreased retina ganglion cell number ( J:124204 )

• apoptosis eliminates most retinal ganglion cells

decreased retina rod cell number ( J:124204 )

• apoptosis eliminates many rod cells

abnormal amacrine cell morphology ( J:124204 )

• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells

• however, markers of SAC differentiation are restored

abnormal retina bipolar cell morphology ( J:124204 )

• apoptosis eliminates most bipolar cells

Allelic Composition	E2f1^tm1Meg/E2f1^tm1Meg E2f3^tm1.1Gle/E2f3^tm1.1Gle Rbl1^tm1Htr/Rbl1^tm1Htr Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background	involves: 129 * C57BL/6 * FVB/N * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1^tm1Meg mutation (2 available); any E2f1 mutation (25 available)
E2f3^tm1.1Gle mutation (0 available); any E2f3 mutation (32 available)
Rbl1^tm1Htr mutation (0 available); any Rbl1 mutation (60 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:124204 )

N	• bipolar and ganglion cell death, starburst amacrine cell (SAC) differentiation, and SAC track disorder observed in Rbl1 null, Rbl1/E2f3 null or Rbl1/E2f1 null mice are rescued

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