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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmc1+
wild type
MGI:2177267
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tmc1Mhdabth/Tmc1+ C3HeB/FeJ-Tmc1Mhdabth/Ieg MGI:2177316
ht2
 		Tmc1dn/Tmc1+ involves: STOCK Grhl3ct * M. m. molossinus MGI:2177314
ht3
 		Tmc1dn/Tmc1+ STOCK Grhl3ct/J MGI:2177315
cx4
 		Tmc1tm1.1Ajg/Tmc1+
Tmc2tm1.1Ajg/Tmc2tm1.1Ajg 		B6.129-Tmc2tm1.1Ajg Tmc1tm1.1Ajg MGI:5427103
cx5
 		Tmc1Mhdabth/Tmc1+
Tmc1m1C57BL/6J/? 		involves: C3HeB/FeJ * C57BL/6J MGI:3663123
cx6
 		Tmc1Mhdabth/Tmc1+
Tmc1m4DBA/2J/? 		involves: C3HeB/FeJ * DBA/2J MGI:3663126
cx7
 		Tmc1Mhdabth/Tmc1+
Tmc1m2DBA/2J/? 		involves: C3HeB/FeJ * DBA/2J MGI:3663124
cx8
 		Tmc1Mhdabth/Tmc1+
Tmc1m3DBA/2J/? 		involves: C3HeB/FeJ * DBA/2J MGI:3663125


Genotype
MGI:2177316
ht1
Allelic
Composition		 Tmc1Mhdabth/Tmc1+
Genetic
Background		 C3HeB/FeJ-Tmc1Mhdabth/Ieg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1Mhdabth mutation (1 available); any Tmc1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:86685 )
• characterized as unsteady

hearing/vestibular/ear
deafness ( J:86685 )
• mice lose ability to hear with four to six weeks
• adult mice are completely deaf




Genotype
MGI:2177314
ht2
Allelic
Composition		 Tmc1dn/Tmc1+
Genetic
Background		 involves: STOCK Grhl3ct * M. m. molossinus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1dn mutation (3 available); any Tmc1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:22445 )
N
• no abnormal ear phenotypes detected




Genotype
MGI:2177315
ht3
Allelic
Composition		 Tmc1dn/Tmc1+
Genetic
Background		 STOCK Grhl3ct/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1dn mutation (3 available); any Tmc1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:14069 )
N
• no abnormal ear phenotypes detected




Genotype
MGI:5427103
cx4
Allelic
Composition		 Tmc1tm1.1Ajg/Tmc1+
Tmc2tm1.1Ajg/Tmc2tm1.1Ajg
Genetic
Background		 B6.129-Tmc2tm1.1Ajg Tmc1tm1.1Ajg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1tm1.1Ajg mutation (1 available); any Tmc1 mutation (59 available)
Tmc2tm1.1Ajg mutation (1 available); any Tmc2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal vestibuloocular dark reflex ( J:184419 )
• reduced acceleration gain values at 2-3 months of age compared to wild-type controls but increased compared to double homozygous mice

hearing/vestibular/ear
abnormal vestibuloocular dark reflex ( J:184419 )
• reduced acceleration gain values at 2-3 months of age compared to wild-type controls but increased compared to double homozygous mice




Genotype
MGI:3663123
cx5
Allelic
Composition		 Tmc1Mhdabth/Tmc1+
Tmc1m1C57BL/6J/?
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1m1C57BL/6J mutation (0 available); any Tmc1m1 mutation (0 available)
Tmc1Mhdabth mutation (1 available); any Tmc1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal distortion product otoacoustic emission ( J:111838 )
• decreased distortion product otoacoustic emission amplitudes
deafness ( J:111838 )
• susceptibility to hearing loss




Genotype
MGI:3663126
cx6
Allelic
Composition		 Tmc1Mhdabth/Tmc1+
Tmc1m4DBA/2J/?
Genetic
Background		 involves: C3HeB/FeJ * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1m4DBA/2J mutation (0 available); any Tmc1m4 mutation (0 available)
Tmc1Mhdabth mutation (1 available); any Tmc1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal distortion product otoacoustic emission ( J:111838 )
• decreased distortion product otoacoustic emission amplitudes
deafness ( J:111838 )
• susceptibility to hearing loss




Genotype
MGI:3663124
cx7
Allelic
Composition		 Tmc1Mhdabth/Tmc1+
Tmc1m2DBA/2J/?
Genetic
Background		 involves: C3HeB/FeJ * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1m2DBA/2J mutation (0 available); any Tmc1m2 mutation (0 available)
Tmc1Mhdabth mutation (1 available); any Tmc1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal distortion product otoacoustic emission ( J:111838 )
• decreased distortion product otoacoustic emission amplitudes
deafness ( J:111838 )
• susceptibility to hearing loss




Genotype
MGI:3663125
cx8
Allelic
Composition		 Tmc1Mhdabth/Tmc1+
Tmc1m3DBA/2J/?
Genetic
Background		 involves: C3HeB/FeJ * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1m3DBA/2J mutation (0 available); any Tmc1m3 mutation (0 available)
Tmc1Mhdabth mutation (1 available); any Tmc1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal distortion product otoacoustic emission ( J:111838 )
• decreased distortion product otoacoustic emission amplitudes
deafness ( J:111838 )
• susceptibility to hearing loss




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory