All Phenotypes Tmc1<Mhdabth> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tmc1^Mhdabth
Martin Hrabe de Angelis beethoven
MGI:2177263

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tmc1^Mhdabth/Tmc1⁺	C3HeB/FeJ-Tmc1^Mhdabth/Ieg	MGI:2177316
cx2	Tmc1^Mhdabth/Tmc1⁺ Tmc1m1^C57BL/6J/?	involves: C3HeB/FeJ * C57BL/6J	MGI:3663123
cx3	Tmc1^Mhdabth/Tmc1⁺ Tmc1m2^DBA/2J/?	involves: C3HeB/FeJ * DBA/2J	MGI:3663124
cx4	Tmc1^Mhdabth/Tmc1⁺ Tmc1m3^DBA/2J/?	involves: C3HeB/FeJ * DBA/2J	MGI:3663125
cx5	Tmc1^Mhdabth/Tmc1⁺ Tmc1m4^DBA/2J/?	involves: C3HeB/FeJ * DBA/2J	MGI:3663126

Allelic Composition	Tmc1^Mhdabth/Tmc1⁺
Genetic Background	C3HeB/FeJ-Tmc1^Mhdabth/Ieg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1^Mhdabth mutation (1 available); any Tmc1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal gait ( J:86685 )

• characterized as unsteady

hearing/vestibular/ear

deafness ( J:86685 )

• mice lose ability to hear with four to six weeks

• adult mice are completely deaf

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
autosomal dominant nonsyndromic deafness 36	DOID:0110563	OMIM:606705	J:86685
autosomal recessive nonsyndromic deafness 7	DOID:0110520	OMIM:600974	J:86685

Allelic Composition	Tmc1^Mhdabth/Tmc1⁺ Tmc1m1^C57BL/6J/?
Genetic Background	involves: C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1m1^C57BL/6J mutation (0 available); any Tmc1m1 mutation (0 available)
Tmc1^Mhdabth mutation (1 available); any Tmc1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal distortion product otoacoustic emission ( J:111838 )

• decreased distortion product otoacoustic emission amplitudes

deafness ( J:111838 )

• susceptibility to hearing loss

Allelic Composition	Tmc1^Mhdabth/Tmc1⁺ Tmc1m2^DBA/2J/?
Genetic Background	involves: C3HeB/FeJ * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1m2^DBA/2J mutation (0 available); any Tmc1m2 mutation (0 available)
Tmc1^Mhdabth mutation (1 available); any Tmc1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal distortion product otoacoustic emission ( J:111838 )

• decreased distortion product otoacoustic emission amplitudes

deafness ( J:111838 )

• susceptibility to hearing loss

Allelic Composition	Tmc1^Mhdabth/Tmc1⁺ Tmc1m3^DBA/2J/?
Genetic Background	involves: C3HeB/FeJ * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1m3^DBA/2J mutation (0 available); any Tmc1m3 mutation (0 available)
Tmc1^Mhdabth mutation (1 available); any Tmc1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal distortion product otoacoustic emission ( J:111838 )

• decreased distortion product otoacoustic emission amplitudes

deafness ( J:111838 )

• susceptibility to hearing loss

Allelic Composition	Tmc1^Mhdabth/Tmc1⁺ Tmc1m4^DBA/2J/?
Genetic Background	involves: C3HeB/FeJ * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1m4^DBA/2J mutation (0 available); any Tmc1m4 mutation (0 available)
Tmc1^Mhdabth mutation (1 available); any Tmc1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal distortion product otoacoustic emission ( J:111838 )

• decreased distortion product otoacoustic emission amplitudes

deafness ( J:111838 )

• susceptibility to hearing loss

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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