Phenotypes associated with this allele

• Allele Symbol: Socs1^tm2Wehi
• Allele Name: targeted mutation 2, Walter and Eliza Hall Institute of Medical Research
• Allele ID: MGI:2177057
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Socs1^tm2Wehi/Socs1^tm2Wehi	C57BL/6-Socs1^tm2Wehi	MGI:3845410

Genotype
MGI:3845410

hm1

• Allelic Composition: Socs1^tm2Wehi/Socs1^tm2Wehi
• Genetic Background: C57BL/6-Socs1^tm2Wehi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:72528 )

• mice start dying around weaning age with 80% of mice dead by 80 days of age

growth/size/body

decreased body weight ( J:72528 )

• weights drop as mice develop inflammatory disease

immune system

thymus atrophy ( J:72528 )

• is observed in 95% of mice

absent spleen germinal center ( J:72528 )

• 55% of mice have no germinal centers in the spleen

increased inflammatory response ( J:72528 )

• mice die from massive generalized inflammation that affects multiple organs

myocarditis ( J:72528 )

• 90% of mice have inflammation in heart muscle

intestinal inflammation ( J:72528 )

• 15% of mice have GI inflammation

salivary gland inflammation ( J:72528 )

• is observed in 61% of mice

pancreas inflammation ( J:72528 )

• is observed in 55% of mice

increased incidence of corneal inflammation ( J:72528 )

• is observed in 53% of mice with 16% of mice having inflammatory ulcers

liver inflammation ( J:72528 )

• is observed in 35-40% of mice

myositis ( J:72528 )

• 90% of mice have inflammation in skeletal muscle

glomerulonephritis ( J:72528 )

• is observed in 15% of mice th 5% of mice having polycystic disease and 5% necrosis

skin inflammation ( J:72528 )

• is observed in 50% of mice

endocrine/exocrine glands

salivary gland inflammation ( J:72528 )

• is observed in 61% of mice

thymus atrophy ( J:72528 )

• is observed in 95% of mice

pancreas inflammation ( J:72528 )

• is observed in 55% of mice

hematopoietic system

thymus atrophy ( J:72528 )

• is observed in 95% of mice

extramedullary hematopoiesis ( J:72528 )

• 55% of mice have erythropoiesis in the spleen

absent spleen germinal center ( J:72528 )

• 55% of mice have no germinal centers in the spleen

cardiovascular system

myocarditis ( J:72528 )

• 90% of mice have inflammation in heart muscle

digestive/alimentary system

intestinal inflammation ( J:72528 )

• 15% of mice have GI inflammation

salivary gland inflammation ( J:72528 )

• is observed in 61% of mice

liver/biliary system

liver inflammation ( J:72528 )

• is observed in 35-40% of mice

muscle

myositis ( J:72528 )

• 90% of mice have inflammation in skeletal muscle

renal/urinary system

glomerulonephritis ( J:72528 )

• is observed in 15% of mice th 5% of mice having polycystic disease and 5% necrosis

vision/eye

increased incidence of corneal inflammation ( J:72528 )

• is observed in 53% of mice with 16% of mice having inflammatory ulcers

integument

skin inflammation ( J:72528 )

• is observed in 50% of mice