Phenotypes associated with this allele

• Allele Symbol: Crygc⁺
• Allele Name: wild type
• Allele ID: MGI:2176924
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Crygc^M2J/Crygc^+	B6(A)-Crygc^M2J/BocJ	MGI:7550444
ht2	Crygc^Lop20/Crygc^+	C;A-Crygc^Lop20/BocJ	MGI:6356349
ht3	Crygc^Chl3/Crygc^+	involves: 102/El * C3H/El	MGI:2176925
ht4	Crygc^MNU8/Crygc^+	involves: 102/El * C3H * T STOCK	MGI:3579823
ht5	Crygc^M1Sbao/Crygc^+	involves: BALB/cJ * ICR	MGI:4822432

Genotype
MGI:7550444

ht1

• Allelic Composition: Crygc^M2J/Crygc⁺
• Genetic Background: B6(A)-Crygc^M2J/BocJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:341260 )

• decreased denucleation compared with wild type and mild disturbances to the central lens compared with homozygotes

cataract ( J:341260 )

• heterozygotes develop minor nuclear opacities encircled by a halo, with the age of onset between 60 and 90 days, and although this phenotype worsens with age the heterozygous lens opacities remain far more mild than those in young homozygotes.

nuclear cataract ( J:341260 )

Genotype
MGI:6356349

ht2

• Allelic Composition: Crygc^Lop20/Crygc⁺
• Genetic Background: C;A-Crygc^Lop20/BocJ

vision/eye

cataract ( J:277888 )

• dense nuclear opacification with irregular edges at the junction between the nucleus and cortex are found by 1 month of age and the cortex subsequently becomes cloudy

cortical cataract ( J:277888 )

nuclear cataract ( J:277888 )

microphthalmia ( J:277888 )

• heterozygotes have eyes that are on average about 75% that of controls

Genotype
MGI:2176925

ht3

• Allelic Composition: Crygc^Chl3/Crygc⁺
• Genetic Background: involves: 102/El * C3H/El

vision/eye

cataract ( J:73804 )

• bilateral nuclear and radial cataracts, less severe than homozygote

• presence of cell nuclei throughout the entire lens

• altered core of the lens with degenerated embryonic primary fiber cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 2 multiple types		DOID:0110235	OMIM:604307	J:73804

Genotype
MGI:3579823

ht4

• Allelic Composition: Crygc^MNU8/Crygc⁺
• Genetic Background: involves: 102/El * C3H * T STOCK

vision/eye

abnormal lens morphology ( J:90087 )

• the lens core is altered

• the lens nucleus appears separated from the outer cortex

abnormal lens fiber morphology ( J:90087 )

• small vacuoles and swollen fiber cells are seen in various parts of the lens

cataract ( J:90087 )

• dense nuclear and subcortical cataracts

• opacity is more severe in homozygotes compared to heterozygotes

Genotype
MGI:4822432

ht5

• Allelic Composition: Crygc^M1Sbao/Crygc⁺
• Genetic Background: involves: BALB/cJ * ICR

Nuclear cataracts in Crygc^M1Sbao/Crygc^M1Sbao and Crygc^M1Sbao/Crygc⁺ mice

vision/eye

abnormal lens morphology ( J:163241 )

• sponge-like and vacuole-like degeneration is observed in the cortical area under the posterior lens capsule unlike in wild-type mice

developmental cataract ( J:163241 )

• at eye opening after birth, mice exhibit lens opacities in the nuclear region and also throughout the eye unlike wild-type mice

nuclear cataract ( J:163241 )

small lens ( J:163241 )

• at P8

abnormal eye physiology ( J:163241 )

• at 3 months, mice exhibit reduction in cornea tension and retinal atrophy unlike wild-type mice