Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm4Kln mutation
(0 available);
any
Efnb2 mutation
(28 available)
Tg(Camk2a-cre)159Kln mutation
(0 available)
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behavior/neurological
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N |
• mice showed no overt behavioral abnormalities
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nervous system
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N |
• normal hippocampal architecture
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• reduced early LTP but no significant defects of basal synaptic transmission parameters or NMDA receptor component
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation
(0 available);
any
Crhr1 mutation
(26 available)
Tg(Camk2a-cre)159Kln mutation
(0 available)
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behavior/neurological
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• in the light-dark box paradigm, mutant mice spend significantly more time in the lit compartment, display a decresead latency to enter the lit compartment, and show a signicantly higher number of entries into the lit compartment than control mice; however, no significant differences in the number of entries into the dark compartment are observed
• in the elevated plus maze test, mutant mice display significantly fewer head-dips in the protected arms as a percentage of total head dips, and an increase in the percentage of entries into the open arms; however, no significant differences in the number of entries into the closed arms are observed
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• mutant mice display increased locomotor activity in the open-field paradigm
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm2Kln mutation
(0 available);
any
Ntrk2 mutation
(66 available)
Tg(Camk2a-cre)159Kln mutation
(0 available)
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nervous system
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• basal synaptic transmission is normal but synaptic strengthening is impaired as evidenced by abnormal long term potentiation
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• there is a reduced induction rate of LTP in hippocampal slices
• induction (measured as a signal 20% above baseline) only occurs 37.0% of the time after burst stimulation compared to 70% in controls
• similar results are observed after tetanus application
• impairment also occurs after long-lasting LTP (L-LTP) that is tested by repeated theta burst
• L-LTP induction rate is 14.2% compared to 62.5% and does not improve with increased stimulus strength
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1Bbd mutation
(2 available);
any
Ntrk2 mutation
(66 available)
Ntrk2tm2Kln mutation
(0 available);
any
Ntrk2 mutation
(66 available)
Tg(Camk2a-cre)159Kln mutation
(0 available)
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behavior/neurological
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• a certain degree of task-specific long-term memory appears to be present but mutants show increasingly impaired learning behavior or inappropriate coping response when facing complex and/or stressful learning paradigms such as in contextual fear conditioning, two-way avoidance, radial maze and water maze learning
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• in avoidance learning, mutants first react normally to the new environment but fall into a persisting maladaptive locomotor activity
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• in the contextual fear conditioning, mutants fail to develop an appropriate freezing response after 30 min but show correct freezing after 24 hours yet not following exposure to tone
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• mutants show impaired spatial learning in the Morris water maze test and partial impairment in the eight-arm radial maze
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• mutants exhibit persistent thigmotaxis in the water maze
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nervous system
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• the number of myelinated axons in the CA1 region of the hippocampus is reduced by 23%
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• reduction in LTP at CA1 hippocampal synapses
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation
(2 available);
any
Bdnf mutation
(41 available)
Tg(Camk2a-cre)159Kln mutation
(0 available)
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behavior/neurological
growth/size/body
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hap1tm2Xjl mutation
(0 available);
any
Hap1 mutation
(37 available)
Tg(Camk2a-cre)159Kln mutation
(0 available)
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behavior/neurological
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• 2 month old mice show increased immobility in the forced swim test and in the tail suspension test
• mice treated with imipramine, a tricyclic antidepressant, show increased mobility in the forced swim test and the tail suspension test
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• mice exhibit lower preference to 1% sucrose solution than controls, indicating anhedonia
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• mice perform better on the rotarod most likely due to smaller body size
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cellular
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• a decrease in proliferating cells is seen in the hippocampal dentate gyrus, indicating a decrease in postnatal neurogenesis
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growth/size/body
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• mild decrease in body weight during postnatal life, however by 4 months of age, weight is similar to controls
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nervous system
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• a decrease in proliferating cells is seen in the hippocampal dentate gyrus, indicating a decrease in postnatal neurogenesis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf1tm1Dmus mutation
(1 available);
any
Gdf1 mutation
(8 available)
Tg(Camk2a-cre)159Kln mutation
(0 available)
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behavior/neurological
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N |
• mice exhibit normal behavior
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nervous system
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N |
• the hippocampus and neurons within the hippocampus are normal
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Analysis Tools