Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Unc mutation
(0 available);
any
Adm mutation
(13 available)
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Generalized edema in Calcrltm1Kmca/Calcrltm1Kmca, Admtm1Unc/Admtm1Unc, and Ramp2tm1Kmca/Ramp2tm1Kmca mice
mortality/aging
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• mice die 1 to 2 days after developing edema
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immune system
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• at E13.5, the jugular lymph sac is smaller than in wild-type mice despite lymphedema
• proliferation of lymphatic endothelial cells is decreased compared to in wild-type mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Unc mutation
(0 available);
any
Adm mutation
(13 available)
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Massive generalized edema of Admtm1Unc/Admtm1Unc embryos
mortality/aging
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• embryos die between E13.5 and E14.5
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cardiovascular system
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• major arteries have thinner walls and are irregular in shape
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• left ventricular trabecular overdevelopment; increased number of trabeculae
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• mutant hearts are 2/3 of the normal size
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• the left ventricle has a thinner, convoluted compact zone
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• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum
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embryo
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• increased apoptosis in the innermost border of the maternal-fetal interface of the placenta at E13.5
• increased apoptosis of parietal trophoblast cells
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• in the innermost border of the maternal-fetal interface of the placenta at E13.5
• fetal vessels are abnormally large and under-branched compared to in wild-type mice
• increase in fetal space is accompanied by a decrease in maternal sinuses
• ovary transplantation experiments demonstrate that placental defects are independent of maternal genotype
• however, the total area of vascular space is normal
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• fetal sinuses of the placenta are larger than in wild-type mice
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• decreased in maternal sinuses
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homeostasis/metabolism
muscle
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• left ventricular trabecular overdevelopment; increased number of trabeculae
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• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum
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cellular
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• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum
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• increased apoptosis in the innermost border of the maternal-fetal interface of the placenta at E13.5
• increased apoptosis of parietal trophoblast cells
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hematopoietic system
immune system
reproductive system
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• reduced maternal spiral artery remodeling with thick smooth muscle layer throughout the decidua
• reduced proliferation of endothelial cells in spiral arteries and failure to shed smooth muscle cells
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endocrine/exocrine glands
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Unc mutation
(0 available);
any
Adm mutation
(13 available)
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cardiovascular system
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• blood pressure under resting conditions and hypotension induced by pregnancy or after LPS treatment is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Unc mutation
(0 available);
any
Adm mutation
(13 available)
Tg(Alb1-Ren)2Unc mutation
(2 available)
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cardiovascular system
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• male cardiomyocytes are larger than in Tg(Alb1-Ren)1Unc male mice
• however, there is no difference in cardiomyocyte size in female mice compared to Tg(Alb1-Ren)1Unc female mice
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• male mice exhibit increased cardiac hypertrophy compared to Tg(Alb1-Ren)1Unc male mice
• however, female mice are not significantly different in terms of cardiac hypertrophy compared to female mice containing Tg(Alb1-Ren)1Unc and the degree of coronary artery fibrosis is the same as in Tg(Alb1-Ren)1Unc mice regardless of gender
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• 149+/-12 mmHg compared to 108+/-9 mmHg in wild-type mice
• however, blood pressure is not significantly different from Tg(Alb1-Ren)1Unc containing mice
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renal/urinary system
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• glomerulosclerosis is worse in male mice than in Tg(Alb1-Ren)1Unc male mice
• however, there is no difference in glomerulosclerosis in female mice compared to Tg(Alb1-Ren)1Unc female mice
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• presence of proteinacious casts is worse in male mice than in Tg(Alb1-Ren)1Unc male mice
• however, there is no difference in presence of proteinacious casts in female mice compared to Tg(Alb1-Ren)1Unc female mice
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• renal fibrosis is worse in male mice than in Tg(Alb1-Ren)1Unc male mice
• however, there is no difference in renal fibrosis in female mice compared to Tg(Alb1-Ren)1Unc female mice
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muscle
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• male cardiomyocytes are larger than in Tg(Alb1-Ren)1Unc male mice
• however, there is no difference in cardiomyocyte size in female mice compared to Tg(Alb1-Ren)1Unc female mice
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growth/size/body
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• male mice exhibit increased cardiac hypertrophy compared to Tg(Alb1-Ren)1Unc male mice
• however, female mice are not significantly different in terms of cardiac hypertrophy compared to female mice containing Tg(Alb1-Ren)1Unc and the degree of coronary artery fibrosis is the same as in Tg(Alb1-Ren)1Unc mice regardless of gender
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Analysis Tools